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SUMMARY:IMX Seminar Series - Injectable synthetic building blocks to regen
 erate soft anisotropic tissues
DTSTART:20201207T131500
DTEND:20201207T141500
DTSTAMP:20260916T064702Z
UID:62661fdd63690d2037a2696cc9b3ed96e9f58967a68053d092886399
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Laura De Laporte\, Leibniz Institute / RWTH Aachen\, Ger
 many\nWe apply polymeric molecular and nano- to micron-scale building bloc
 ks to assemble soft 3D biomaterials with anisotropic and dynamic propertie
 s. Microgels and fibers are produced by technologies based on fiber spinni
 ng\, microfluidics\, and in-mold polymerization. To arrange the building b
 locks in a spatially controlled manner\, self-assembly mechanisms and asse
 mbly by external magnetic fields are employed. For example\, the Anisogel 
 technology offers a solution to regenerate sensitive tissues with an orien
 ted architecture\, which requires a low invasive therapy. It can be inject
 ed as a liquid and structured in situ in a controlled manner with defined 
 biochemical\, mechanical\, and structural parameters. Magnetoceptive\, ani
 sometric microgels or short fibers are incorporated to create a unidirecti
 onal structure. Cells and nerves grow in a linear manner and the fibronect
 in produced by fibroblasts is aligned. Regenerated nerves are functional w
 ith spontaneous activity and electrical signals propagating along the anis
 otropy axis of the material. Another developed platform is a thermorespons
 ive hydrogel system\, encapsulated with plasmonic gold-nanorods\, which ac
 tuates by oscillating light. This system elucidates how rapid hydrogel bea
 ting leads to a reduction in cell migration\, while enhancing focal adhesi
 ons\, native production of extracellular matrix\, and nuclear translocatio
 n of mechanosensitive proteins\, depending on the amplitude and frequency 
 of actuation.
LOCATION:Zoom https://epfl.zoom.us/j/95940364570
STATUS:CONFIRMED
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