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SUMMARY:DLN: Tissue engineering and bioelectronic devices for disease mode
 lling and drug discovery
DTSTART:20201020T121500
DTEND:20201020T130000
DTSTAMP:20260407T131945Z
UID:68bfbd9506c530059b4f27cc65ff57d287e53be5b047ddf7c06d4a66
CATEGORIES:Conferences - Seminars
DESCRIPTION:Róisín M. Owens (University of Cambridge\, UK)\nIn vitro mod
 els of biological systems are essential for our understanding of biologica
 l systems\, to model disease and develop novel therapies. In many cases wh
 ere animal models have failed to translate to useful data for human diseas
 es\, physiologically relevant in vitro (human) models can bridge the gap. 
 Many difficulties exist in interfacing complex\, 3D models with technology
  adapted for monitoring function. Polymeric electroactive materials and de
 vices can bridge the gap between hard inflexible materials used for physic
 al transducers and soft\, compliant biological tissues. An additional adva
 ntage of these electronic materials is their flexibility for processing an
 d fabrication in a wide range of formats.(1) Our work seeks to engineer ti
 ssues with polymeric transducers built into the heart of the tissue\, avoi
 ding post hoc integration. We therefore tailor our transducers to be as bi
 omimetic as possible to enable seamless interfacing with tissues and high 
 fidelity signal transduction.(2) An example of this work is our developmen
 t of a 3D porous electrode used to host and monitor a model of the human i
 ntestine\, which I will showcase in this talk. In the second part of my pr
 esentation I will highlight recent research using biomimetic models of cel
 l membranes interfaced with organic electronic devices for ion channel mon
 itoring and virus fusion detection.(3)\n\n\n1.         J. Rivnay\, 
 S. Inal\, A. Salleo\, R. M. Owens\, M. Berggren\, G. G. Malliaras\, Organi
 c electrochemical transistors. Nat. Rev. Mater. 3\, 17086 (2018).\n2.   
       C. Pitsalidis\, M. P. Ferro\, D. Iandolo\, L. Tzounis\, S. Inal
 \, R. M. Owens\, Transistor in a tube: A route to three-dimensional bioele
 ctronics. Sci. Adv. 4\, eaat4253 (2018).\n3.         A.-M. Pappa\, 
 H.-Y. Liu\, W. Traberg-Christensen\, Q. Thiburce\, A. Savva\, A. Pavia\, A
 . Salleo\, S. Daniel\, R. M. Owens\, Optical and Electronic Ion Channel Mo
 nitoring from Native Human Membranes. ACS Nano (2020)\, doi:10.1021/acsnan
 o.0c01330.\n 
LOCATION:By zoom https://epfl.zoom.us/j/84812682597
STATUS:CONFIRMED
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