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SUMMARY:How do transcription factors engage their motifs in a chromatinize
 d genome?
DTSTART:20201211T110000
DTEND:20201211T120000
DTSTAMP:20260430T183939Z
UID:e6476edf91106e3ae3272cd530365c1ea5b3c57017dca6229c1d85db
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Nicolas Thomä\n \nMy lab focuses on the fundamental work
 ings of DNA binding proteins\, particularly transcription\nand repair fact
 ors. We are interested in how these proteins operate in the context of chr
 omatin\,\nwhere nucleosomes frequently gate access to DNA and play an impo
 rtant role in repair and\ngene regulation. A particular focus of the lab i
 s on studying the link between chromatin binding\nfactors and ubiquitin bi
 ology. By dissecting the detailed mechanism of molecular glue drugs\,\na n
 ovel class of small molecule therapeutics that induce proximity between a 
 protein and a\nubiquitin ligase\, we have provided the molecular basis of 
 how the drug thalidomide (also\nknown as Contergan) successfully degrades 
 transcription factors. Recent work from my\nlaboratory showed how small mo
 lecules can induce other unexpected neo-morphic\ninteractions between prot
 eins\, a previously unanticipated phenomenon intrinsic to many\nknown drug
 s. These studies offer insight into the fundamental workings of genome-bou
 nd\nprotein machines\, the forces that govern protein-protein interactions
 \, and the ways in which\nprotein interactions can be reprogrammed by smal
 l molecules.
LOCATION:WEBINAR https://epfl.zoom.us/j/113660323
STATUS:CONFIRMED
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