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SUMMARY:A Walk in the Garden of Forking Paths
DTSTART:20200929T121500
DTSTAMP:20260427T225638Z
UID:770baa89d5a68b7432f287c4b74c055352e9c1761fef38162c1e2101
CATEGORIES:Conferences - Seminars
DESCRIPTION:Giovanni D'Angelo\, Lipid Cell Biology Laboratory\, EPFL\nIn t
 he framework of our GHI Floor Seminars\, we are happy to host Giovanni D'A
 ngelo (Lipid Cell Biology Laboratory – Kristian Gerhard Jebsen Chair on 
 Metabolism).\n\nCOVID-19: the talk will be held in SV 1717 but allow a max
 imum of 30 people to attend the seminar\, on a first come first served bas
 is. Mask is mandatory. The talk will be streamed via Zoom to allow everyon
 e else to participate. If you are not a GHI member and wish to attend the 
 seminar\, please register following this link: https://epfl.zoom.us/meeti
 ng/register/tJAkfuyoqzsqEtxFujqV5KheYMCUrcg31IiS\n\nA Walk in the Garden o
 f Forking Paths\nAbstract:\nEukaryotic cells produce thousands of lipids t
 hat contribute to specific biological functions. Thanks to lipidomics\, we
  now appreciate the lipid compositional dynamics of the cell. Lipidomes in
 deed vary among cell types and change in differentiation events. Lipid com
 position also changes from cell to cell in otherwise homogeneous populatio
 ns contributing to cell heterogeneity. So far\, biologists have addressed 
 lipidomes in bulk cell extracts or selected lipids at the single-cell leve
 l. Thus\, which cell-to-cell lipid variations have biological meaning rema
 ins largely undefined. Here\, by using high-resolution mass spectrometry i
 maging\, we have analyzed the lipidome of hundreds of individual human der
 mal fibroblasts in situ. We found that: (i) specific lipid metabolic segm
 ents (i.e.\, the sphingolipid pathways) are cell-to-cell variable\; (ii) g
 iven lipid configurations mark discrete cell states\; (iii) and that sphin
 golipids modulate dermal fibroblast activation involved in skin developme
 nt and wound healing . These data uncover a role for lipid heterogeneity 
 in the determination of cell states and in tissue homeostasis and reveal a
  new regulatory component to the self-organization of multicellular system
 s.    
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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