BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Blue Brain Seminar - Cell-specific cholinergic modulation of neoco
 rtical neurons
DTSTART:20201001T110000
DTEND:20201001T120000
DTSTAMP:20260509T054624Z
UID:c9fe158d1858ee6d05e48a936192b775a5066b4a865cd8a17b04b7af
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dirk Feldmeyer\nOnline Event  \nBlue Brain is delighted to a
 nnounce that the next seminar in the series in Neural Computation\, will b
 e on ‘Cell-specific cholinergic modulation of neocortical neurons’. Th
 e seminar will be given by Dirk Feldmeyer\, Professor\, University Hospita
 l Medical School Aachen\, and Professor and Group Leader\, Research Centre
  Jülich.\n\nAbstract:\nAcetylcholine (ACh) is a potent neuromodulator in 
 the brain and is in the neocortex mainly released from afferents of the ba
 sal forebrain. The effects of ACh are mediated by both G-protein coupled r
 eceptors and ligand-gated ion channels termed muscarinic and nicotinic ACh
  receptors (mAChRs and nAChRs). While nAChR activation leads exclusively t
 o an enhancement of neuronal firing and synaptic transmission\,  mAChR ca
 n inhibit or activate neurons depending on the specific receptor subtype e
 xpression.\nUsing the primary somatosensory barrel cortex as a model syste
 m I will present data on how neuronal activity is modulated by the interac
 tion of different types of mAChR subtype but also nAChRs. I will demonstra
 te that in the different cortical layers ACh can show exclusively excitato
 ry\, exclusively inhibitory and a combination of both effects\, depending 
 on the neuron type and its axonal projection pattern. In addition\, I will
  also describe how both mAChRs and nAChRs affect the synaptic release prob
 ability and how this compares to its effects on neuronal excitability. Our
  finding support the hypothesis that mAChR effects are mediated already at
  low extracellular concentration (1-10 µM) while nAChRs are generally act
 ivated at significantly higher concentrations (> 100 µM). This is consist
 ent with the view that activation of mAChRs occurs either via volume relea
 se of the transmitter or spill-over from cholinergic synapses. In contrast
 \, nAChRs are mainly activated by direct synaptic release\; however\, some
  presynaptic nAChRs may also be activated via spill-over. Thus\, the actio
 n of ACh in the neocortex is complex\, highly neuron-specific\, and depend
 s on the type of synaptic connection.\n\n\nBio:\nDirk Feldmeyer is profess
 or at the Department of Psychiatry\, Psychotherapy and Psychosomatics\, Un
 iversity Hospital Medical School\, Aachen and professor and group leader a
 t the Institute of Neuroscience and Medicine 10\, Research Centre Jülich\
 , Germany.\nDirk is also an Associate Editor for Frontiers and an elected 
 Fellow of the Physiological Society.\nHe began his career in 1988 as a Pos
 t-doc at the Dept of Cell Physiology (Director Prof. Hans Lüttgau)\, Ruhr
 -University Bochum before moving to University College London for four yea
 rs as a Postdoc and Research Fellow at the Dept of Pharmacology followed b
 y a year in the Dept of Neuroscience\, University of Tokyo as a Research F
 ellow. In 1995\, he became the Post-doc and Group Leader at Dept. of Cell 
 Physiology\, Max-Planck-Institute for Medical Research (Director Prof. B. 
 Sakmann\, Noble Prize Laureate)\; Head of ‘Cortical microcircuits’ Gro
 up. Since 2004\, he has been the Group Leader and Principal Investigator a
 t the Institute of Medicine\, Research Centre Jülich where he also held t
 he role of Head of the FZJ Animal Facility\, Research Centre Jülich for f
 our years. Dirk was appointed Professor at the Dept. of Psychiatry\, Psych
 otherapy and Psychosomatics\, University Hospital Medical School\, Aachen 
 in 2008.\n 
LOCATION:Zoom meeting https://epfl.zoom.us/meeting/register/tJcocuitqDMpGt
 SEXLV4bqzmlRLNkWtcD9uM
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR