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SUMMARY:EPFL BioE Talks SERIES  "GOLPH3 Coordinates Glycosphingolipid Meta
 bolism at the Golgi Complex"
DTSTART:20201005T163000
DTEND:20201005T170000
DTSTAMP:20260510T110221Z
UID:29efd553951e3c84b4de2a79fcf214de2d8298931eda1d080407706b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Giovanni D'Angelo\, Institute of Bioengineering\, EPFL\,
  Lausanne (CH)\nWEEKLY EPFL BIOE TALKS SERIES\n\n(note that this talk is n
 umber two of a double-feature seminar - see details of the first talk here
 )\n\nAbstract:\nThe Golgi apparatus is a hub for several metabolic pathway
 s including those involving glycan and lipid syntheses. These metabolisms
  rely on competing reactions catalysed by Golgi-resident enzymes during t
 he passage of substrates through the Golgi cisternae. While the relative 
 position of the enzymes within the Golgi stack determines the reaction seq
 uence and the metabolic output\, the mechanisms that coordinate the intra-
 Golgi localization of the enzymes are poorly understood. Here\, we studied
  GOLPH3\, an oncoprotein with a reported role in Golgi enzymes localizatio
 n. We found that GOLPH3 binds to and regulates multiple sequentially-acti
 ng enzymes of the glycosphingolipid synthesis. GOLPH3 drives their dynamic
  localisation at the trans Golgi\, counteracts their transport to lysoso
 mes and consequent degradation. Through these effects\, increased GOLPH3 l
 evels\, as those observed in solid tumours\, foster glycosphingolipid prod
 uction and exposure at the external leaflet of the plasma membrane. Here\,
  glycosphingolipids promote mitogenic signalling and cell proliferation. 
 Our findings unravel the mechanisms by which Golgi recycling drives the lo
 calization of specific enzymes in the appropriate cisternae\, their degra
 dation rate\, and their organization into functional modules that impact d
 istinctive metabolic pathways. Moreover\, our data have medical implicati
 ons as they outline a novel oncogenic mechanism of action for GOLPH3 bas
 ed on glycosphingolipid metabolism.\n\n\nZoom link (with registration) f
 or attending remotely: https://go.epfl.ch/EPFLBioETalks\n\n\nIMPORTANT NOT
 ICE: due to restrictions resulting from the ongoing Covid-19 situation\, t
 his seminar can be followed via Zoom web-streaming only\, following prior 
 one-time registration through the link above.
LOCATION:via Zoom web-streaming only\, due to Covid-19 situation https://g
 o.epfl.ch/EPFLBioETalks
STATUS:CONFIRMED
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