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SUMMARY:Dictyostelium as a model phagocyte to study both cell-autonomous a
 nd altruistic defence against (myco)bacteria infection
DTSTART:20201013T121500
DTSTAMP:20260603T131126Z
UID:9acd02ca2fe6eb273ea1cdc1e4e21ee60ae22286a5c8eb78d3bcd336
CATEGORIES:Conferences - Seminars
DESCRIPTION:Thierry Soldati\, Biochemistry\, UNIGE\nThe first line of defe
 nce against bacterial infections are phagocytic cells of the innate immune
  system. While multicellular organisms use phagocytosis to kill microbes a
 nd initiate a sustained immune response\, phagocytic amoebae internalise b
 acteria as nutrients\, via mechanisms of recognition\, signalling and kill
 ing that are surprisingly conserved with innate immune phagocytes. Dictyos
 telium is a social amoeba that feeds by phagocytosis and has ancestral\, h
 ighly conserved cell-autonomous defence systems. It is genetically and bio
 chemically tractable and has emerged as a powerful and experimentally vers
 atile model to study various bacterial pathogens. The causative agent of t
 uberculosis\, Mycobacterium tuberculosis\, infects alveolar macrophages an
 d subverts their bactericidal pathways that normally protect the lungs fro
 m infection. Important aspects of mycobacteria pathogenicity and host defe
 nces during infection remain to be explored. We study the mechanisms of in
 fection by Mycobacterium marinum\, a close cousin of M. tuberculosis\, whi
 ch uses similar virulence strategies to re-program and proliferate inside 
 macrophages. In particular\, we use this Dictyostelium/M. marinum model to
  study the inter-relationships between host and pathogen in terms of nutri
 tional immunity\, acquisition of metabolites\, interference with the membr
 ane trafficking and cytsokeletal processes. Recently\, we have strongly fo
 cused on the pathways responding and repairing bacteria-mediated membrane 
 damages\, manipulation of autophagy and acquisition of lipids from the hos
 t. We have also used this infection model to perform medium-throughput scr
 eens for anti-infective compounds with low antibiotic activity that reveal
 ed the possibility to develop compounds for host-directed anti-infectious 
 strategies.\n\nSV 1717\nWe encourage you to come in the SV1717 room - with
  a mask! But we will limit the number of people to 30. There will be a si
 gn-up sheet in the seminar room.\n\nZoom\nTo join the meeting\, use the 
 following link: https://epfl.zoom.us/meeting/register/tJAkfuyoqzsqEtxFujq
 V5KheYMCUrcg31IiS to register.
LOCATION:SV 1717 & Zoom https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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