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SUMMARY:BMI SEMINAR - Webinar // Matthew Larkum: Neocortical layer 1 – t
 he memory layer?
DTSTART:20210113T121500
DTEND:20210113T131500
DTSTAMP:20260916T074423Z
UID:6b41fbb9ab073ffcc81faf071835266057347957e5dd169ee00af69a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Matthew Larkum\,  Humboldt University\, Berlin\, Germany\nArg
 uably one of the biggest mysteries in neuroscience is how the brain stores
  long-term memories. The major challenge for investigating the neural circ
 uit underlying memory formation in the neocortex is the distributed nature
  of the resulting memory trace throughout the cortex. Here\, we used a new
  behavioral paradigm that enabled us to generate memory traces in a specif
 ic cortical location and to specifically examine the mechanisms of memory 
 formation in that region. We found that medial-temporal inputs arrive in n
 eocortical layer 1 where the apical dendrites of cortical pyramidal neuron
 s predominate. These dendrites have active properties that make them sensi
 tive to contextual inputs from other areas that also send axons to layer 1
  around the cortex. Blocking the influence of these medial-temporal inputs
  prevented learning and suppressed resulting dendritic activity. We conclu
 de that layer 1 is the locus for hippocampal-dependent memory formation in
  the neocortex and propose that this process enhances the sensitivity of t
 he tuft dendrites to contextual inputs.\n 
LOCATION:Online
STATUS:CONFIRMED
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