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SUMMARY:Breaking the rules with natural and non-natural cyclic peptides
DTSTART:20201117T161500
DTEND:20201117T171500
DTSTAMP:20260921T035735Z
UID:5278fea148fdfd0ebcb513010a1f3142d34d28258a7cb820b87650f8
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Scott Lokey\, UC Santa Cruz\nThe laboratory of Prof. Sco
 tt Lokey is studying the membrane permeability in molecules whose structur
 es violate classical predictors of “drug-likeness” (e.g. Lipinski's "r
 ule of five") based on molecular weight and polarity. Many of these ”ru
 le breakers” are natural products such as the cyclic peptide cyclosporin
 e A\, a highly effective immunosuppressive drug that is orally bioavailabl
 e despite its molecular weight of ~1200. The Lokey lab is investigating th
 e physico-chemical properties of molecules like cyclosporine and\, using 
 synthetic model systems\, are uncovering interesting relationships between
  structure\, conformation\, and membrane permeability in these molecules.\
 n 
LOCATION:Zoom https://epfl.zoom.us/j/87665377407
STATUS:CONFIRMED
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