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VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:EPFL BioE Talks SERIES  "High-Throughput Super-Resolution Microsco
 py for Reconstructing Molecular Architecture"
DTSTART:20201109T163000
DTEND:20201109T170000
DTSTAMP:20260603T231328Z
UID:9d222fd3e5fa5ab4b716e1e83d7095af60a017476ccaaf26603cc0eb
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Suliana Manley\, Institute of Physics and Institute of B
 ioengineering\, EPFL\, Lausanne (CH)\nWEEKLY EPFL BIOE TALKS SERIES\n\n(no
 te that this talk is number two of a double-feature seminar - see details 
 of the first talk here)\n\nAbstract:\nSuper-resolution microscopy is an im
 portant tool because it enables imaging beyond the diffraction limit\, whi
 le maintaining the specificity and live-cell possibilities of fluorescence
  microscopy. Yet\, many important biological questions remain out of reach
  due to challenges in acquiring and analyzing statistically significant da
 tasets. We created a uniform illumination scheme to enable high quality\, 
 large field of view PALM/STORM\, and now iSIM images. We demonstrate the p
 ower of this approach for studying large\, multi-protein complexes within 
 cells\, using the centriole as a case study. To study the organization of 
 such complexes\, particle-based analysis has proven to be powerful\, but h
 as been limited so far by difficulties in generating large multi-color par
 ticle libraries\, as well as the complexity of orientational alignment. We
  have addressed both challenges and\, as a result\, present a framework fo
 r deciphering the 3D organization of protein complexes composed of multipl
 e components.\n\nBio:\nBorn in the United States\, Suliana Manley studied 
 at Rice University where she obtained a bachelor’s degree in physics and
  mathematics in 1997\, cum laude. She continued her studies at Harvard Uni
 versity\, where she earned a PhD in physics under the supervision of Prof.
  Dave Weitz in 2004. After this\, she conducted postdoctoral research on l
 ipid bilayer and red blood cell membrane dynamics at MIT. She subsequently
  went on to work as a postdoctoral researcher in the cell biology laborato
 ry of Jennifer Lippincott-Schwartz at the National Institutes of Health (U
 SA). During this time\, she developed a highly promising optical method (s
 ptPALM) for studying the dynamics of large ensembles of single proteins in
  membranes and inside cells. She became a tenure-track assistant professor
  of physics at the EPFL in 2009\, and was promoted to associate professor 
 with tenure in 2016.\n\nZoom link (with registration) for attending remote
 ly: https://go.epfl.ch/EPFLBioETalks\n\n\nIMPORTANT NOTICE: due to restric
 tions resulting from the ongoing Covid-19 situation\, this seminar can be 
 followed via Zoom web-streaming only\, following prior one-time registrati
 on through the link above.
LOCATION:via Zoom web-streaming only\, due to Covid-19 situation https://g
 o.epfl.ch/EPFLBioETalks https://go.epfl.ch/EPFLBioETalks
STATUS:CONFIRMED
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