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SUMMARY:EPFL BioE Talks SERIES  "Extracellular Matrix Viscoelasticity and 
 Its Impact on Cells"
DTSTART:20201116T160000
DTEND:20201116T163000
DTSTAMP:20260414T175458Z
UID:384f71ec9d44abb52f628494b0ae4fbf9fabeffafc38a4dab491c2a5
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Ovijit Chaudhuri\, Stanford University\, Stanford\, CA (
 USA)\nWEEKLY EPFL BIOE TALKS SERIES\n \n(note that this talk is number on
 e of a double-feature seminar - see details of the second talk here)\n\nAb
 stract:\nThe extracellular matrix (ECM) is a complex assembly of structura
 l proteins that provides physical support and biochemical signaling to cel
 ls in tissues. Over the last two decades\, studies have revealed the impor
 tant role that ECM elasticity plays in regulating a variety of biological 
 processes in cells\, including stem cell differentiation and cancer progre
 ssion. However\, tissues and ECM are often viscoelastic\, displaying stres
 s relaxation over time in response to a deformation\, and can exhibit mech
 anical plasticity. My group has been focused on elucidating the impact of 
 ECM elasticity\, viscoelasticity\, and plasticity on cells. Our approach i
 nvolves the use engineered biomaterials for 3D culture\, in which the mech
 anical properties can be independently modulated. In this talk\, I will di
 scuss our recent findings on the impact of ECM viscoelasticity on cartilag
 e matrix formation by chondrocytes and cell-cycle progression\, the regula
 tion of cancer cell invasion and migration by matrix plasticity\, and the 
 transcriptional and epigenetic regulation of mechanotransduction in breast
  cancer progression.\n\nBio:\nDr. Ovijit Chaudhuri is an Assistant Profess
 or in the Department of Mechanical Engineering at Stanford University. He 
 earned a B.S. in engineering physics with a minor in mathematics at UC Ber
 keley. Then\, he obtained his Ph.D. in bioengineering at UC Berkeley and U
 C San Francisco\, studying force generation and mechanics of actin cytoske
 letal networks with Prof. Daniel Fletcher. From there\, he went on to do a
  postdoctoral fellowship at Harvard University\, studying cell mechanotran
 sduction and developing engineered biomaterials for 3D culture with Prof. 
 David Mooney. He joined Stanford in 2013\, and his research interests are 
 in cell biophysics and mechanotransduction.  His honors include a DARPA y
 oung faculty award\, an NSF CAREER award\,an American Cancer Society resea
 rch scholar award\, and a National Research Service Award. His group’s r
 esearch has been supported by the NIH\, the NSF\, the American Cancer Soci
 ety\, DARPA\, and Stanford’s Bio-X Institute. More information about his
  group’s work can be found at https://chaudhurilab.stanford.edu.\n\n\n\
 nZoom link (with registration) for attending remotely: https://go.epfl.ch/
 EPFLBioETalks\n\n\nIMPORTANT NOTICE: due to restrictions resulting from th
 e ongoing Covid-19 situation\, this seminar can be followed via Zoom web-s
 treaming only\, following prior one-time registration through the link abo
 ve.
LOCATION:via Zoom web-streaming only\, due to Covid-19 situation https://g
 o.epfl.ch/EPFLBioETalks https://go.epfl.ch/EPFLBioETalks
STATUS:CONFIRMED
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