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SUMMARY:Imaging cell signaling by high spatial-temporal resolution fluores
 cence spectroscopy - Paolo Annibale
DTSTART:20201204T141500
DTEND:20201204T150000
DTSTAMP:20260413T094602Z
UID:41377809db3fa36290dad91f3c1ccbd835a0e1167f138d93e7eed93f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Paolo Annibale\n\nI am a cell biologist and biophysicist with 
 over ten years of experience as a research microscopist\, first using scan
 ning probe methods\, then fluorescence fluctuations and superresolution te
 chniques. This expertise builds on top of a training in solid state physic
 s\, molecular electronics and semiconducting thin films matured working in
  Italy\, Switzerland the US and now Germany. I am currently leading a smal
 l team in Berlin researching fundamental molecular mechanisms modulating G
  protein-coupled Receptors (GPCR) signaling and the underlying pharmacolog
 y\, within the context of a grant of the German Research Foundation.\nCell
  signaling\, in particular that mediated by G Protein-Coupled Receptors (G
 PCRs)\, entails multiple levels\, starting from ligand binding\, proceedin
 g with receptor activation\, coupling to downstream signaling partners and
  finally generation of second messenger molecules. Each of these steps\, c
 an be finely modulated by the local environment that the key signaling pro
 teins are experiencing within the cell. In multiple instances\, this subce
 llular modulation is responsible for surprisingly diverse responses to app
 arently similar stimuli. The molecular mechanisms responsible for this het
 erogeneous subcellular response can be visualized and investigated by a to
 olbox of high spatial and temporal resolution fluorescence spectroscopy me
 thods\, which I will introduce in this talk together with relevant example
 s.
LOCATION:https://epfl.zoom.us/j/85457926365
STATUS:CONFIRMED
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