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SUMMARY:EPFL BioE Talks SERIES  "The Challenges and Promises of DNA as Pro
 grammable Biomaterial"
DTSTART:20201207T163000
DTEND:20201207T170000
DTSTAMP:20260405T193117Z
UID:b6ef9feb5a2b5b9331f4a608f70fd6e150a6e54f2ecda084d08e2afc
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Maartje M.C. Bastings\, Institute of Materials and Insti
 tute of Bioengineering\, EPFL\, Lausanne (CH)\nWEEKLY EPFL BIOE TALKS SERI
 ES\n\n(note that this talk is number two of a double-feature seminar - see
  details of the first talk here)\n\nAbstract:\nDNA-nanotechnology offers u
 nprecedented control over the precise structure and location in a nanostru
 cture since each element has a unique sequence. In the DNA-origami method\
 , a 7-kilobase “scaffold” strand is self-assembled with hundreds of sh
 orter “staple” strands to form a parallel array of double helices.[1] 
 Using this method\, one can approximate any desired three-dimensional shap
 e up to the size of a small virus.[2][3] The technology suffers however fr
 om inherent stability challenges when used in cellular environments.[4]\n\
 nIn this talk\, I will start with a brief overview of the DNA nanotechnolo
 gy principles and will go into depth on stabilization solutions that allow
  for cellular manipulation using DNA architectures.[5][6] We developed DNA
 -nanostructures with the aim to selectively target cells as well as study 
 the shape related cellular uptake in various cell types.[7] Finally\, I wi
 ll touch upon our activities to explore precise activation of the immune s
 ystem through controlled maturation of dendritic cells. By systematic scre
 ening of immune-pathway activation of DNA-origamis combined with antigens 
 and danger-signals\, we are making small steps into a better understanding
  of the complex mechanisms of our immune system. This knowledge holds pote
 ntial to be translated toward the development of vaccines for autoimmune d
 iseases and cancer.\n\nReferences:\n[1]P. W. K. Rothemund\, “Folding DNA
  to create nanoscale shapes and patterns\,” Nature\, 440\, 7082\, 297–
 302\, 2006.\n[2]S. M. Douglas\, H. Dietz\, T. Liedl\, F. Graf\, W. M. Shih
 \, and B. Högberg\, “Self-assembly of DNA into nanoscale three-dimensio
 nal shapes\,” Nature\, 459\, 7245\,  414–418\, 2009.\n[3]H. Dietz\, S
 . M. Douglas\, and W. M. Shih\, “Folding DNA into twisted and curved nan
 oscale shapes\,” Science\, 325\, 5941\, 725–30\, 2009.\n[4]J. Hahn\, S
 . F. J. Wickham\, W. M. Shih\, and S. D. Perrault\, “Addressing the Inst
 ability of DNA Nanostructures in Tissue Culture\,” 8\, 9\, 8765-8775\, 2
 014\n[5]N. Ponnuswamy et al.\, “Oligolysine-based coating protects DNA n
 anostructures from low-salt denaturation and nuclease degradation\,” Nat
 . Commun.\, 8\, 15654\, 2017.\n[6]H. Bila\, E. E. Kurisinkal\, and M. M. C
 . Bastings\, “Engineering a stable future for DNA-origami as a biomateri
 al\,” Biomater. Sci.\, 2019.\n[7]M. M. C. Bastings et al.\, “Modulatio
 n of the Cellular Uptake of DNA Origami through Control over Mass and Shap
 e\,” Nano Lett.\, 2018.\n\n\nBio:\nMaartje Bastings\, PhD (1984)\, studi
 ed Biomedical Engineering at the Eindhoven University of Technology (200
 3-2008). University of California\, Santa Barbara and California Institut
 e of Technology\, Pasadena. Maartje combined her undergraduate studies in
  Biomedical Engineering with a professional education in classical flute
  on the Fontys Conservatory\, Tilburg (BMus\, 2007).\nShe performed her P
 hD research in the group of prof.dr. E.W. (Bert) Meijer\, working on the u
 nderstanding of multivalent binding mechanisms for directed targeting and 
 the development of dynamic biomaterials for tissue engineering and success
 fully defended her thesis titled “Dynamic Reciprocity in Bio-Inspired Su
 pramolecular Materials” in September 2012. Her thesis was awarded the U
 niversity Academic Award (2013) for best university-wide PhD thesis.\nFro
 m November 2012 – December 2016\, Maartje worked as a postdoctoral fell
 ow at the Wyss Institute / Harvard University in Boston\, USA.\nSince Ja
 nuary 2017\, she is appointed at EPFL as tenure track assistant profes
 sor\, heading the Programmable Biomaterials Laboratory (PBL). Her quest is
  to use DNA as a precision engineering tool to unravel the role of spatial
  organization in multivalent interactions.\n\n\nZoom link (with registrati
 on) for attending remotely: https://go.epfl.ch/EPFLBioETalks\n\n\nIMPORTAN
 T NOTICE: due to restrictions resulting from the ongoing Covid-19 situatio
 n\, this seminar can be followed via Zoom web-streaming only\, following p
 rior one-time registration through the link above.
LOCATION:via Zoom web-streaming only\, due to Covid-19 situation https://g
 o.epfl.ch/EPFLBioETalks https://go.epfl.ch/EPFLBioETalks
STATUS:CONFIRMED
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