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SUMMARY:EPFL BioE Talks SERIES  "DNA Origami Coating Strategies for Enhanc
 ed Stability and Delivery"
DTSTART:20201207T160000
DTEND:20201207T163000
DTSTAMP:20260609T230409Z
UID:9457c522107dcd5ec264b3c36e2547f4e05b1ee0b2d11a633c040d56
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Mauri A. Kostiainen\, Aalto University\, Espoo (SF)\nWEE
 KLY EPFL BIOE TALKS SERIES\n \n(note that this talk is number one of a do
 uble-feature seminar - see details of the second talk here)\n\nAbstract:\n
 Fully addressable DNA nanostructures\, especially DNA origami\, possess hu
 ge potential to serve as inherently biocompatible and versatile molecular 
 platforms. However\, their use as delivery vehicles in therapeutics is com
 promised by their low stability and poor transfection rates. Our studies h
 ave shown that DNA origamis can be coated non-covalently by various materi
 als to tackle the aforementioned issues. In detail\, we have demonstrated 
 that coatings utilizing either virus capsid proteins\, serum albumin\, pht
 halocyanine dyes or cationic lipids can enhance the delivery\, and especia
 lly stability of the structures. The electrostatic complexation strategy i
 s highly modular and suitable for a wide range of DNA-based templates.\n\n
 References:\nMikkilä\, J.\; Eskelinen\, A.-P.\; Niemelä\, E.\; Linko\, V
 .\; Frilander\, M.\; Törmä\, P.\; Kostiainen\, M. A. Virus Encapsulated 
 DNA Origami Nanostructures for Cellular Delivery\, Nano Letters\, 2014\, 1
 4\, 2196-2200.\nAuvinen\, H.\; Zhang\, H.\; Nonappa\; Kopilow\, A.\; Nieme
 lä\, E. H.\; Nummelin\, S.\; Ikkala\, O.\; Santos\, H. A.\; Linko\, V.\; 
 Kostiainen\, M. A. Protein Coating of DNA Nanostructures for Enhanced Stab
 ility and Immunocompatibility\, Advanced Healthcare Materials\, 2017\, 6\,
  1700692.\nShaukat\, A.\; Anaya-Plaza\, E.\; Julin\, S.\; Linko\, V.\; Tor
 res\, T.\; de la Escosura\, A.\; Kostiainen\, M. A. Phthalocyanine-DNA Ori
 gami Complexes with Enhanced Stability and Optical Properties\, Chemical C
 ommunications\, 2020\, 56\, 7341-7344.\n\n\nBio:\nMauri A. Kostiainen obta
 ined his Ph.D. in engineering physics from Helsinki University of Technolo
 gy\, Finland (2008). After receiving his doctoral degree\, he spent 2.5 ye
 ars at the Radboud University Nijmegen (The Netherlands) developing new ap
 proaches for chemical and physical virology. He returned to Aalto Universi
 ty in 2011 as an Academy of Finland postdoctoral fellow and joined the Sch
 ool of Chemical Engineering in 2013\, where he is currently an Associate P
 rofessor. His research interests focus on the integration of biological an
 d synthetic building blocks in a designed manner to create biohybrid mater
 ials.\n\n\n\n\n\nZoom link (with registration) for attending remotely: htt
 ps://go.epfl.ch/EPFLBioETalks\n\n\nIMPORTANT NOTICE: due to restrictions r
 esulting from the ongoing Covid-19 situation\, this seminar can be followe
 d via Zoom web-streaming only\, following prior one-time registration thro
 ugh the link above.
LOCATION:via Zoom web-streaming only\, due to Covid-19 situation https://g
 o.epfl.ch/EPFLBioETalks https://go.epfl.ch/EPFLBioETalks
STATUS:CONFIRMED
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