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SUMMARY:BMI Progress Reports 2021 // Prof. Gräff's Lab: L. Dixsaut "Where
  does the engram come from? Study of prefrontal cortical inputs during mem
 ory consolidation"
DTSTART:20210922T121500
DTEND:20210922T130000
DTSTAMP:20260408T035010Z
UID:daccfb6840f75c608369ea47fc9a3027597e7759bedcf70082f3f25d
CATEGORIES:Conferences - Seminars
DESCRIPTION:L. Dixsaut\nThe formation and storage of memories has been und
 er deep investigation for several decades. Nevertheless\, the precise mech
 anisms by which memories are initially encoded and subsequently stored in 
 different brain areas are still unknown. However\, we can theoretically de
 fine cells carrying a memory as engram cells that are activated at the tim
 e of learning\, that undergo enduring molecular modifications after learni
 ng\, that are reactivated upon recall of the memory and which reactivation
  drives the recall itself. Recent evidence has suggested that the medial p
 refrontal cortex (mPFC) contains engram cells already at encoding\, but in
  contrast to hippocampal engram cells\, mPFC engram cells are kept silent 
 during the recall until the memory is fully consolidated. These findings s
 tipulate that inputs to the mPFC are differentially activated over the cou
 rse of memory consolidation.\nIn order to identify the activation patterns
  of specific cortical projections\, we screened the activity of mPFC input
 s throughout consolidation of a fear memory using an unbiased retrograde t
 racing in adult mice. We further tested their functional relevance by chem
 ogenetically inhibiting these projections during the different learning ph
 ases. This highlighted the role of Claustrum and Basolateral Amygdala inpu
 ts to the mPFC during the encoding of the fear memory\, as well as the sur
 prising influence of the Insular cortex input at recent recall. This indic
 ates that there might be a switch occurring in the mPFC inputs during cons
 olidation.  Finally\, we investigated the effect of those manipulations o
 n the reactivation of the original mPFC engram using the engram tagging cF
 os-tTA mouse line.\nCollectively\, our data help to further refine the wor
 king model of memory formation by deciphering the interplay between brain 
 regions during the process of systems consolidation of a fear memory.\n 
LOCATION:Online
STATUS:CONFIRMED
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