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SUMMARY:BMI Progress Reports 2021 // Prof. Markram's Lab: Rajnish Ranjan -
  Kinetic characterization of voltage-gated ion channels - A case study on 
 HCN channels
DTSTART:20211006T121500
DTEND:20211006T130000
DTSTAMP:20260414T111007Z
UID:e8c19661a14d99f869407469148d1fcb81d2d62720a4a1f04542d69f
CATEGORIES:Conferences - Seminars
DESCRIPTION:E. Svensson\nVoltage-gated ion channels (VGICs) are membrane p
 roteins that selectively allow ions to pass through the membrane\, creatin
 g an electrical potential across the cell membrane. Although VGIC genes we
 re fully sequenced decades ago\, a comprehensive kinetic characterization 
 of VGICs is still missing\, especially near physiological temperature. VGI
 Cs kinetic data is key to the understanding of excitable cell physiology a
 nd is considered among the essential data needed for the biophysically det
 ailed neuron modelling.\nTherefore\, we have been systematically character
 izing the kinetic properties of VGICs across different temperatures and in
  this talk I will present the key findings from patch-clamp recordings of 
 main VGICs (Kv\, Kir\, K2P\, HCN\, Nav\, Cav) and as a case study the deta
 iled kinetic characterization of HCN channels across temperatures\, specie
 s and known modulators (cAMP and ZD7288).
LOCATION:Online
STATUS:CONFIRMED
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