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SUMMARY:BMI Progress Reports 2021 // Prof. McCabe's Lab: Soumya Banerjee -
  The GEF Trio is required for the age-dependent maintenance of synapses
DTSTART:20211117T121500
DTEND:20211117T130000
DTSTAMP:20260415T191308Z
UID:2fc473bbe8313334bd48a76ff06f6d22e98e98b1e7da9b2974384ae7
CATEGORIES:Conferences - Seminars
DESCRIPTION:TBD\nThe decline of neuronal synapses is an established featur
 e of ageing accompanied by the diminishment of neuronal function\, and in 
 the motor system at least\, a reduction of behavioural ability. Recently\,
  using a novel adult motor synapse preparation\, we have investigated Dros
 ophila synaptic terminals during ageing. We observed cumulative fragmentat
 ion of presynaptic structures accompanied by diminishment of both evoked a
 nd miniature neurotransmission occurring in tandem with reduced motor abil
 ity. Building upon these observations\, we have previously established tha
 t miniature neurotransmission is essentially required for the age-dependen
 t structural maintenance of synapses (Banerjee et al. 2021).   Here\, we
  have sought to identify novel factors that can ameliorate age-dependent s
 ynapse structural dissolution. From a candidate screen\, we identified tha
 t the guanine exchange factor (GEF) Trio is required to maintain synaptic 
 architecture during ageing. We show that Trio is localised at neuromuscula
 r presynaptic neurotransmitter release sites and that levels of Trio decli
 ne as animals age. We find that premature loss of Trio induces synaptic fr
 agmentation similar to that which occurs during ageing and\, importantly\,
  that increasing Trio levels can ameliorate the synaptic degeneration and
  motor decline of aged animals. Our results reveal that the decline of mo
 tor synaptic structures and behavioural capacity during ageing can be defe
 rred.\n 
LOCATION:Online
STATUS:CONFIRMED
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