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SUMMARY:DLN: Mapping early brain network changes in neurodegenerative and 
 cerebrovascular disorders: a longitudinal perspective\, Prof. Helen Zhou
DTSTART:20210119T121500
DTEND:20210119T130000
DTSTAMP:20260416T033210Z
UID:50facc826c6394049760c2295ce7538750734ec6b6a077cc620ca311
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof Juan (Helen) Zhou\nAbstract\nThe spatial patterning of ea
 ch neurodegenerative disease relates closely to a distinct structural and 
 functional network in the human brain. This talk will mainly describe how 
 brain network-sensitive neuroimaging methods such as resting-state fMRI an
 d diffusion MRI can shed light on brain network dysfunctions associated wi
 th pathology and cognitive decline from preclinical to clinical dementia. 
 I will first present our findings from two independent datasets on how amy
 loid and cerebrovascular pathology influence brain functional networks cro
 ss-sectionally and longitudinally in individuals with mild cognitive impai
 rment and dementia. Evidence on longitudinal functional network organizati
 onal changes in healthy older adults and the influence of APOE genotype wi
 ll be presented. In the second part\, I will describe our work on how diff
 erent pathology influences brain structural network and white matter micro
 structure. I will also touch on some new data on how brain network integri
 ty contributes to behavior and disease progression using multivariate or m
 achine learning approaches. These findings underscore the importance of st
 udying selective brain network vulnerability instead of individual region 
 and longitudinal design. Further developed with machine learning approache
 s\, multimodal network-specific imaging signatures will help reveal diseas
 e mechanisms and facilitate early detection\, prognosis and treatment sear
 ch of neuropsychiatric disorders.\n\n\n\nDr. Juan (Helen) Zhou is an Assoc
 iate Professor and Principal Investigator of the Multimodal Neuroimaging i
 n Neuropsychiatric Disorders Laboratory in the Center for Sleep and Cognit
 ion\, Department of Medicine\, Yong Loo Lin School of Medicine\, National 
 University of Singapore (NUS). She also holds a joint appointment with Neu
 roscience and Behavioral Disorders Program at Duke-National University of 
 Singapore Medical School\, Singapore. Dr. Zhou serves as the Deputy Direct
 or\, Center for Translational Magnetic Resonance Research MR operations at
  Yong Loo Lin School of Medicine. Her research focuses on the network-base
 d vulnerability hypothesis in disease. Her lab studies the human neural ba
 ses of cognitive functions and the associated vulnerability patterns in ag
 ing and neuropsychiatric disorders using multimodal neuroimaging methods\,
  psychophysical techniques\, and machine learning approaches.\nPrior to jo
 ining NUS in 2011\, Helen was an associate research scientist in the  Depa
 rtment of Child and Adolescent Psychiatry (New York University). She did a
  two-year post-doctoral fellowship at the  Memory and Aging Centre (Depart
 ment of Neurology\, University of California\, San Francisco)\, from 2008 
 to 2010. Helen received her Bachelor degree in Computer Science with first
  class honour (First class\, 3.5 years accelerated) in 2003 and her Ph.D. 
 in Neuroimaging in 2008 from  Nanyang Technological University\, Singapore
 . She is the recipient of undergraduate scholarship from Ministry of Educa
 tion\, Singapore (1998-2003) and the nominee for Lee Kuan Yew Gold Medal a
 nd the Institution of Engineers Singapore Gold Medal\, Singapore in 2004.\
 nHelen has published in a number of journals such as Neuron\, Brain\, PNAS
 \, Neurology\, NeuroImage\, and Molecular Psychiatry and has been the reci
 pient of research support from National Medical Research Council and Biome
 dical Research Council\, Singapore as well as the Royal Society\, UK. She 
 serves as reviewers and editors for a number of journals (NeuroImage\, Hum
 an Brain Mapping\, Communications Biology) and grants. She is the Council 
 – Secretary and Program Committee Member of the Organization for Human B
 rain Mapping. She is a member of the Organization for Human Brain Mapping\
 , Society for Neuroscience\, International Society to Advance Alzheimer’
 s Research and Treatment\, International Society of Magnetic Resonance in 
 Medicine\, and American Academy of Neurology.
LOCATION:Online https://epfl.zoom.us/s/89531291401
STATUS:CONFIRMED
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