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SUMMARY:Constructing and de-constructing brain network activity in the mou
 se
DTSTART:20210113T110000
DTEND:20210113T120000
DTSTAMP:20260407T114645Z
UID:e8283fa08bffa7e3c6d223f2873e6685837323067367bb8a1228a73a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Valerio Zerbi\n\nSummary: While molecules and cells are the bi
 ological building blocks of the brain\, virtually all behaviours arise as 
 a result of computations that are implemented through neural interactions 
 within macro-scale networks. However\, mechanistic insight into how specif
 ic neuronal signalling at the cell level translates into changes in macros
 copic connectivity is limited. In my lab\, we use functional neuroimaging\
 , neural modulation and computational approaches to uncover the basic mech
 anisms that link network-level brain signals with the underlying cellular 
 activity\, in health and disease. In this talk\, I will be giving an overv
 iew of my past work and discuss more in details about the role of the Locu
 s Coeruleus / Norepinephrine system in reconfiguring communication between
  large-scale networks in the brain.\n\nBiosketch: Valerio Zerbi got his ma
 ster degree in Biomedical Engineering (2008) at the Politecnico of Milano\
 , Italy. Thereafter he moved to the Netherlands\, where he obtained a PhD 
 in Medical Sciences (2013) at the Radboud University Nijmegen Medical Cent
 re\, Nijmegen\, as well as the diploma at the Donders Graduate School for 
 Cognitive Neuroscience. In 2014 he moved to Zurich\, where he won an ETH P
 ostdoctoral Fellowship award\, to work in the lab of Prof. Nici Wenderoth.
  Since 2017 Valerio is a Swiss National Science Foundation (SNSF) Ambizion
 e fellow. He is currently leading an independent research team of 3 PhD St
 udents. Valerio has dedicated his research efforts on advancing the field 
 of rodent functional neuroimaging. His work has thus far provided the crit
 ical foundation for using preclinical fMRI as a translational tool (i) for
  studying the interactions between brain structure and function at multipl
 e spatial scales\, (ii) for detecting deviations in network connectivity i
 n numerous mouse models of neurodegenerative and neurodevelopmental disord
 ers\, (iii) for identifying the effects of cell manipulation on large-scal
 e networks (using  pharmacological\, chemogenetics and optogenetics inter
 ventions) and (iv) for studying the principles of brain evolution. More re
 cently\, he has been the first to apply simultaneous chemogenetic of the L
 ocus Coeruleus with fMRI to study how this reconfigures communication betw
 een large-scale networks in the brain.His long-term ambition is to change 
 the use and interpretation of neuroimaging data\, from a descriptive appro
 ach towards a mechanistic understanding of their biological meaning.\n
LOCATION:https://epfl.zoom.us/j/86973440718
STATUS:CONFIRMED
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