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SUMMARY:MechE Colloquium: Cybergenetics: Rationally-designed genetic contr
 ol systems
DTSTART:20181030T121500
DTEND:20181030T131500
DTSTAMP:20260407T183957Z
UID:c5b9ac08af9eee8f20c7c03890ef7f9a38102b4233b1f10b78480f24
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Mustafa Khammash\, Control Theory and Systems Biology La
 boratory\, Department of Biosystems Science and Engineering\, ETH Zürich\
 nAbstract:\nHumans have been influencing the DNA of plants and animals for
  thousands of years through selective breeding. Yet it is only over the la
 st 3 decades or so that we have gained the ability to manipulate the DNA i
 tself and directly alter its sequences through the modern tools of genetic
  engineering. This has revolutionized biotechnology and ushered in the era
  of synthetic biology. Among the possible applications enabled by syntheti
 c biology is the design and engineering of feedback control systems that a
 ct at the molecular scale in real-time to steer the dynamic behavior of li
 ving cells. Here I will present our theoretical framework for the design a
 nd synthesis of such control systems\, and will discuss the main challenge
 s in their practical implementation. I will then present the first designe
 r gene network that attains integral feedback in a living cell and demonst
 rate its tunability and disturbance rejection properties. A growth control
  application shows the inherent capacity of this integral feedback control
  system to deliver robustness\, and highlights its potential use as a univ
 ersal controller for regulation of biological variables in arbitrary netwo
 rks. Finally\, I will discuss the potential impact of biomolecular control
  systems in industrial biotechnology and medical therapy and bring attenti
 on to the opportunities that exist for control theorists to advance this y
 oung area of research.\n\nBio:\nMustafa Khammash is the Professor for Cont
 rol Theory and Systems Biology at the Department of Biosystems Science and
  Engineering at ETH Zurich\, Switzerland. He works in the areas of control
  theory\, systems biology\, and synthetic biology. His lab develops theore
 tical\, computational\, and experimental methods aimed at understanding th
 e role of dynamics\, feedback\, and randomness in biology. He is currently
  developing new theoretical and experimental approaches for the design of 
 biomolecular control systems and for their realization in living cells.\n\
 nProf. Khammash received his B.S. degree from Texas A&M University in 1986
  and his Ph.D. from Rice University in 1990\, both in electrical engineeri
 ng. In 1990\, he joined the engineering faculty of Iowa State University\,
  where he created the Dynamics and Control Program and led the control gro
 up until 2002. He then joined the engineering faculty at the University of
  California\, Santa Barbara (UCSB)\, where he was Director of the Center f
 or Control\, Dynamical Systems and Computation (CCDC) until 2011 when he j
 oined ETH Zurich. He is a Fellow of the IEEE\, IFAC\, and the Japan Societ
 y for the Promotion of Science (JSPS).
LOCATION:MED 0 1418 https://plan.epfl.ch/?room==MED%200%201418
STATUS:CONFIRMED
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