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SUMMARY:Multiplexed in vivo imaging with near and shortwave infrared polym
 ethine fluorophores
DTSTART:20210406T170000
DTEND:20210406T183000
DTSTAMP:20260427T225336Z
UID:87bdf4064125eceefdd94b93a34903b66f3028956cf5bcf833fe4f7d
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Ellen Sletten\, University of California Los Angeles\nFl
 uorescence imaging is a central tool for visualizing complex biological sy
 stems\, yet the contrast and resolution attainable in vivo is limited due 
 to autofluorescence and light scattering at visible and near infrared (NIR
 ) wavelengths. Recently\, the shortwave infrared region of the electromagn
 etic spectrum (SWIR\, 1000 – 2000 nm) has emerged as an optimal region f
 or in vivo fluorescence imaging due to few endogenous SWIR chromophores an
 d minimized scattering of light by tissue. While the SWIR demonstrates gre
 at promise\, suitable materials are needed with emission at these low ener
 gies for the development of optical contrast agents. Namely\, non-toxic or
 ganic small molecules with bright emission > 1000 nm are necessary to expa
 nd both the basic science and clinical applications of fluorescence imagin
 g.\n\nOur group has developed biocompatible polymethine fluorophores with 
 shortwave infrared emission. We discovered a bright shortwave infrared flu
 orophore containing flavylium heterocycles that we deemed Flav7. We have s
 ystematically investigated Flav7 using physical organic chemistry approach
 es and can now predictably tune the absorption and emission properties. Th
 ese insights have led to new SWIR fluorophores that enable multiplexed rea
 l time in vivo imaging and the fastest SWIR imaging to date.
LOCATION:https://epfl.zoom.us/j/86757408722
STATUS:CONFIRMED
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