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SUMMARY:Synthetic biology approaches to study and exploit RNA regulation
DTSTART:20210413T161500
DTEND:20210413T171500
DTSTAMP:20260530T093634Z
UID:52f10bd298764969f311c79ec4f7cecf4166977a39eca12d6b868632
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof Bryan Dickinson earned his B.S. in Biochemistry from the 
 University of Maryland\, College Park and his Ph.D. in Chemistry from the 
 University of California at Berkeley for work performed with Professor Chr
 istopher Chang. His graduate work focused on the synthesis and application
  of small molecule fluorescent probes for the detection of hydrogen peroxi
 de in living systems. Then\, as a Jane Coffin Childs Memorial postdoctoral
  fellow with Professor David Liu at Harvard University\, he developed new 
 methods to rapidly evolve proteins to perform novel functions. Bryan joine
 d the faculty at the University of Chicago in the Department of Chemistry 
 in the Summer of 2014 and is a member of the University of Chicago Compreh
 ensive Cancer Center. He was promoted to Associate Professor in 2019. The 
 Dickinson Group employs synthetic organic chemistry\, molecular evolution\
 , and protein design to develop molecular technologies to study chemistry 
 in living systems. The group's current primary research interests include:
  1) how lipid modifications on proteins are controlled and regulate cell s
 ignaling\, 2) developing new evolution technologies to reprogram and contr
 ol biomolecular interactions\, and 3) engineering systems to understand an
 d exploit epitranscriptomic\, RNA regulation. The motivating principle of 
 the Dickinson Group is that our ability as chemists to create functional m
 olecules through both rational and evolutionary approaches will lead to ne
 w breakthroughs in biology and biotechnology.\nRNA transcribed from the ge
 nome in the nucleus bears little resemblance to the RNA polymer it will ul
 timately become in the cytoplasm where it is translated into protein. Well
 -known processes such as capping\, splicing and polyadenylation\, as well 
 as the recently discovered and ever-expanding list of diverse chemical mod
 ifications and editing\, significantly alter the properties and fates of a
  given RNA during the course of its lifetime.\n\nThese alterations regulat
 e critical aspects of RNA function such as stability\, transport\, protein
  binding\, and translation. Especially in mammalian systems\, these post-t
 ranscriptional gene expression regulatory processes are often a key determ
 inant of genetic information flow. Moreover\, from an engineering and ther
 apeutic perspective these RNA regulatory processes represent new ways to c
 ontrol or retune gene expression at the RNA level\, if they can be harness
 ed.\n\nI will present several technologies our group has developed to meas
 ure the chemical composition and localization of RNAs\, and to measure and
  control protein-RNA interactions with an eye toward therapeutic developme
 nt.
LOCATION:https://epfl.zoom.us/j/82539880760
STATUS:CONFIRMED
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