BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:CIS - "Get to know your neighbors" Seminar series - Prof. Bruno Co
 rreia
DTSTART:20210201T151500
DTEND:20210201T161500
DTSTAMP:20260427T224608Z
UID:244dbe9a7e891d7831e849804aaa034f0a06a996a85ae50fe27a7be8
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Bruno Correia\nTitle: Deciphering interaction fingerprin
 ts from protein molecular surfaces using geometric deep learning \nAbstra
 ct: Predicting interactions between proteins and other biomolecules solely
  based on structure remains a central challenge in biology. A high-level r
 epresentation of protein structure\, the molecular surface\, displays patt
 erns of chemical and geometric features that fingerprint a protein’s mod
 es of interactions with other biomolecules.\nThe underlying hypothesizes o
 f our work is that proteins interacting with similar molecules may share c
 ommon fingerprints\, independent of their sequence and overall structural 
 fold. These structural fingerprints are difficult to grasp by visual analy
 sis but may be learned from large-scale datasets.\nI will discuss MaSIF (M
 olecular Surface Interaction Fingerprinting)\, a conceptual framework base
 d on a geometric deep learning method\, to capture structural fingerprints
  that are important for specific biomolecular interactions. I will also pr
 esent current developments of the framework to make it end-to-end differen
 tiable. Finally\, I will describe our approach based on MaSIF to design de
  novo protein-protein interactions\, which may have important applications
  in the development of new protein-based drugs.   \nWe anticipate that t
 his conceptual framework will lead to improvements in our understanding of
  protein function and design.\nBio: Throughout my PhD and postdoctoral stu
 dies\, I was trained in world-renowned laboratories and institutions in th
 e United States of America (University of Washington and The Scripps Resea
 rch Institute). Very early in my scientific career I found out my fascinat
 ion about protein structure and function. My PhD studies evolved in the di
 rection of immunogen design and vaccine engineering\, which sparked my int
 erest in the many needs and opportunities in vaccinology and translational
  research. My efforts resulted in an enlightening piece of work where for 
 the first time\, computationally designed immunogens elicited potent neutr
 alizing antibodies. During my postdoctoral studies\, I joined a chemical b
 iology laboratory at the Scripps Research Institute. In this stage\, I dev
 eloped novel chemoproteomics methods for the identification of protein-sma
 ll molecule interaction sites in complex proteomes. In March 2015\, I join
 ed the École Polytechnique Fédérale de Lausanne (EPFL) – Switzerland 
 as a tenure track assistant professor. The focus of my research group is t
 o develop computational tools for protein design with particular emphasis 
 in applying these strategies to immunoengineering (e.g. vaccine and cancer
  immunotherapy). The activities in my laboratory focus on computational de
 sign methods development and experimental characterization of the designed
  proteins. Our laboratory has been awarded with 2 prestigious research gra
 nts from the European Research Council. Lastly\, I have been awarded the p
 rize for best teacher of Life sciences in 2019. \n\nThe Center for Intel
 ligent Systems at EPFL (CIS) is a collaboration among IC\, SB\, STI and 
 ENAC that brings together researchers working on different aspects of Inte
 lligent Systems.\n \nIn order to promote exchanges among researchers and 
 encourage the creation of new\, collaborative projects\, CIS is organizing
  a "Get to know your neighbors" series. Each seminar will consist of one s
 hort overview presentation geared to the general public at EPFL.\n \nThe 
 CIS seminar will take place live on Zoom:https://epfl.zoom.us/j/8814556801
 4\n\n\n \nMonday\, 1st February 2021 from 3:15 to 4:15 pm\n\n\nNB: Video 
 recordings of the seminars will be made available on our website and publi
 shed on our social media pages
LOCATION:Zoom https://epfl.zoom.us/j/88145568014 https://epfl.zoom.us/j/88
 145568014
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR