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SUMMARY:Sjors SCHERES: Reconstruction of Cryo-EM Images of Proteins to Ato
 mic Resolution
DTSTART:20210415T170000
DTEND:20210415T180000
DTSTAMP:20260916T203810Z
UID:ad5aed44be36d368ba04ec99aa346a02f3dc91680ef199e1a67628cb
CATEGORIES:Conferences - Seminars
DESCRIPTION:Sjors Scheres\, MRC Laboratory of Molecular Biology\, UK \nTh
 is event is part of the EPFL Seminar Series in Imaging (https://imagingsem
 inars.org).\n\nAbstract. The three-dimensional positions of atoms in prote
 in molecules define their structure and their roles in biological processe
 s. The more precisely atomic coordinates are determined\, the more chemica
 l information can be derived and the more mechanistic insights into protei
 n function may be inferred. Electron cryo-microscopy (cryo-EM) single-part
 icle analysis has yielded protein structures with increasing levels of det
 ail in recent years. However\, it has proved difficult to obtain cryo-EM r
 econstructions with sufficient resolution to visualize individual atoms in
  proteins.\n\nI will introduce the general principles of cryo-EM reconstru
 ction and present how we recently used new electron microscopy hardware an
 d software to calculate cryo-EM reconstructions of a test protein (apoferr
 itin) to atomic resolution. Our technological advances\, combined with fur
 ther approaches to accelerate data acquisition and improve sample quality\
 , provide a route towards routine application of cryo-EM in high-throughpu
 t screening of small molecule modulators and structure-based drug discover
 y.\n\nBiography. Sjors Scheres is a Group Leader at the MRC Laboratory of
  Molecular Biologoy\, Cambridge. He is also joint Head of the Structural S
 tudies division there. His main interests lie in the development of new me
 thods for high-resolution cryo-EM structure determination\, and their appl
 ication to amyloid filaments.
LOCATION:https://epfl.zoom.us/j/82126986503
STATUS:CONFIRMED
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