BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Using Chemistry to Understand the O-GlcNAc Posttranslational Modif
 ication
DTSTART:20210216T173000
DTEND:20210216T184500
DTSTAMP:20260510T064911Z
UID:553e7c924d0ca92c6ab7f6a88d5f9aa47c6ae0c8538f5f3e69685aab
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Matthew Pratt (USC)\nO-GlcNAc modification is the dynami
 c addition of the monosaccharide N-acetylglucosamine to intracellular prot
 eins. Genetic experiments have demonstrated that this modification is esse
 ntial for development in insects and is required for basic cell survival i
 n mammals. Changes in the levels of O-GlcNAc are associated with various d
 iseases\, including cancer and diabetes where the levels are elevated and 
 neurodegenerative diseases were they are decreased. Despite the clearly im
 portant role for O-GlcNAc in in human health and disease\, the effects of 
 the modification on specific proteins and cellular pathways are still murk
 y. Unfortunately\, for a variety of reasons\, traditional biological appro
 aches are poorly suited to study O-GlcNAc. To overcome these limitations\,
  we employ a range of chemical tools including chemical probes and inhibit
 ors and protein synthesis. In this seminar\, I will talk about two O-GlcNA
 c discoveries. First\, I will explain how we used small-molecule inhibitor
 s to discover how O-GlcNAc controls the sensitivity of a signaling pathway
  that results in cellular contraction and motility. Second\, I will descri
 be our use of protein chemistry to prepare site-specifically O-GlcNAcylate
 d proteins and show that the modification is a multifaceted inhibitor of a
 myloid protein aggregation. \n\n 
LOCATION:https://epfl.zoom.us/j/81548074478
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR