BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Sliding\, Pushing\, Crashing: the Treacherous Pathways of Chromoso
 me Replication in a Crowded World
DTSTART:20210511T161500
DTEND:20210511T173000
DTSTAMP:20260916T060033Z
UID:be363f26c85c8c3535b5521ade36f8ae328adf7d14ae06f714bdec7a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Karl Duderstadt (MPI Biochemistry\, München)\nLife as we know
  it is the product of fundamental physical laws and randomness. This inter
 play shapes biology on all time and length scales\, from the dynamics of p
 opulations to the most basic cellular processes. On the molecular scale\, 
 where key transactions require energies not far above those of thermal flu
 ctuations\, noise is intrinsic and dominant. Nevertheless\, how chance enc
 ounters and random events influence molecular pathways is not well underst
 ood. In this seminar\, these ideas will be explored in the context of chro
 mosome replication where a broad range of structurally diverse challenges 
 frequently arise. We gain access to these dynamics using single-molecule i
 maging approaches that provide direct observations of the stochastic event
 s that reshape molecular pathways. In particular\, how transcription-repli
 cation conflicts can forever alter the pathway of replisome assembly will 
 be presented and how replisomes overcome intrinsic features of chromosome 
 architecture including nucleosomes and unfavorable topological states will
  be discussed. Taken together\, these studies reveal a surprising resilien
 ce in replication pathways that helps to ensure chromosome integrity and t
 he faithful transfer of genetic information from one generation to the nex
 t.
LOCATION:https://epfl.zoom.us/j/88089196947
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR