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SUMMARY:MechE Colloquium: A short story from soft tissues dissipation to t
 he development of hydrogels for medical applications
DTSTART:20210413T121500
DTEND:20210413T131500
DTSTAMP:20260407T010650Z
UID:c6b4f8237b2e68ecf08ebea96d679827ef2e6e79b5d47670c0951255
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Dominique Pioletti\, Laboratory of Biomechanical Orthope
 dics (LBO)\, EPFL School of Engineering (STI)\, Interschool Institute of B
 ioengineering (IBI-STI)\nAbstract:\nTo quote Prof Clifford Truesdell\, “
 dissipation is the rule rather than the exception”. The study of this ph
 enomenon is therefore of prime importance if we want to obtain a precise d
 escription of the mechanical behavior and the biological functions of soft
  tissues. As example\, we previously showed that the dissipation arising i
 n knee cartilage during physical activities was responsible for a local te
 mperature increase in this tissue favoring chondrogenesis. Dissipation is 
 however a general term that does not discriminate between the different di
 ssipation sources at play in soft tissues submitted to dynamic loading. Th
 e dissipation sources can be of reversible or irreversible nature which ha
 ve fundamental different physical properties. In this talk\, I will presen
 t the way we consider and control the dissipative phenomena in the develop
 ment of materials such as hydrogels to increase their mechanical propertie
 s. In particular\, I will highlight the central aspect of dissipation in d
 eveloping highly adhesive hydrogels or soft materials that could be used i
 n the prevention of concussion in sport contact.\n\nBio:\nAfter an undergr
 aduate study in Physics at EPFL\, Dominique Pioletti pursued his education
  in the same Institution and obtained his PhD in biomechanics in 1997. He 
 developed original constitutive laws for soft tissues taking into account 
 viscoelasticity in large deformation situations. Then he spent two years a
 t UCSD as a post-doc fellow and was interested in particular to understand
  the molecular and cellular mechanisms leading to peri-implant osteolysis.
  He developed at that time the pioneer idea to use orthopedic implant as d
 rug delivery system and has since proposed different solutions relevant fo
 r clinical applications. Since his return at EPFL\, he combined biomechani
 cal\, biological and materials science aspects to developed new solutions 
 for clinical problems related to the musculoskeletal system. In particular
 \, he co-founded a start-up (flowbone.com) to translate the development of
  an injectable hydrogel use to prevent osteoporotic fracture. His research
  topics include biomechanics of the musculoskeletal system\, mechanobiolog
 y in bone and cartilage\, drug delivery system for bone and cartilage\, an
 d functional tissue engineering. His close collaboration with different ho
 spital departments has resulted in research output oriented toward applica
 tions.
LOCATION:https://epfl.zoom.us/j/82207717593
STATUS:CONFIRMED
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