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SUMMARY:IMX Seminar Series - An Instagram View of the Nanoworld
DTSTART:20210315T131500
DTEND:20210315T141500
DTSTAMP:20260601T105423Z
UID:60a9e78e5cb980a785032e7ee8f78885b7549aeedee76c11c068e9e1
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Deb Kelly\, Penn State University\, USA\nBiomedical rese
 arch improves our understanding of human health and disease through the de
 velopment of new technologies. High-resolution imaging is one technology t
 hat is transforming our view of the nanoworld – permitting us to study c
 ells and molecules in exquisite detail. Structural information of dynamic 
 components\, however\, reveals only an instant of their complex narrative.
 \n\nRecent advances in the production of materials such as graphene and si
 licon nitride provide new opportunities for EM imaging in real-time. We us
 e these materials to create environmental chambers and perform experiments
  in situ\, or “inside”\, the EM column. Together\, with microfluidic t
 echnology\, we can now view biological processes in a native liquid enviro
 nment at the nanoscale (Fig. 1a). Other recent applications of in situ ima
 ging include real-time recordings of nanoparticle therapies interacting wi
 th cancer stem cells and changes in the molecular intricacies of viral pat
 hogens. These results complement our ongoing cryo-EM studies on tumor supp
 ressor proteins (Fig. 1b\, c) as we strive to analyze molecular events wit
 h high spatial and temporal resolution.\nBio: Deb Kelly completed her PhD 
 in Molecular Biophysics at Florida State University and her post-doctoral
  training in Structural Biology at Harvard Medical School. During these p
 ursuits\, she developed technical breakthroughs in the field of cryo-EM th
 at are now being used by the in situ TEM community. As interest in situ TE
 M has skyrocketed in recent years\, the Kelly team has been on the leading
 -edge of adapting this technology for biomedical applications\, in particu
 lar cancer research. Dr. Kelly is currently a professor of Biomedical Engi
 neering at the Pennsylvania State University\, where the holds the Lloyd a
 nd Dottie Foehr Huck Chair in Molecular Biophysics and directs the Center 
 for Structural Oncology (CSO). The CSO focuses on combating the molecular 
 culprits that fuel human cancer while revealing the hidden enemies that ca
 ncer cells use to outsmart modern medicine. \n\n 
LOCATION:https://epfl.zoom.us/j/95940364570
STATUS:CONFIRMED
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