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SUMMARY:Probing Biological Dynamics in the Native State: From Long-Term Br
 ain Electrophysiology to Subcellular Dynamic Imaging
DTSTART:20210302T160000
DTEND:20210302T170000
DTSTAMP:20260408T041516Z
UID:67f46293cdd49fa7cffa4053ee158ca104fcab6a9ae67ac0b6c0fad2
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Tian-Ming Fu\nPlease note that the schedule of the event st
 ill has to be confirmed\n\nThe urgency to probe and understand dynamics in
  biology is impeded by a major challenge in bioinstrumentation development
 . The large dynamic range of biological processes—interactions of molecu
 les within milliseconds result in changes across whole-organisms over year
 s—calls for instruments with both high spatiotemporal resolution and lar
 ge-scale long-term coverage. However\, high resolution measurement often r
 equires frequent and invasive sampling\, which limits the spatiotemporal c
 overage of the instruments. In this seminar\, I will present two independe
 nt yet complementary approaches that tackle this challenge. First\, I wil
 l introduce a new paradigm—syringe-injectable mesh electronics—for sea
 mlessly merging electronics with mammalian brains. The gliosis-free and th
 ree-dimensional interpenetrated brain-electronics interface enables stable
  stimulation and recording from the same neurons and neural circuits over 
 a year. I will then discuss the application of mesh electronics to retina 
 electrophysiology in awake mice. Second\, I will describe a novel multimod
 al optical scope with adaptive imaging correction (MOSAIC) to observe subc
 ellular dynamics inside multicellular organisms with high spatiotemporal r
 esolution\, large imaging depth and low phototoxicity. I will present appl
 ications of MOSAIC to various model organisms\, including transcription fa
 ctor kinetics in embryoid bodies\, axonal targeting in Drosophila\, cance
 r metastasis and embryogenesis in Caenorhabditis elegans and zebrafish. 
 Both the electrical and optical approaches opened up new windows to probe 
 dynamics in biology with minimum perturbation and expanded spatiotemporal 
 ranges.\nBiography: Dr. Tian-Ming Fu obtained his B.S. in Math and Physics
  from Tsinghua University in 2011. He did his Ph.D. with Dr. Charles Liebe
 r at Harvard University. His graduate work focused on the development of s
 yringe-injectable mesh electronics (http://meshelectronics.org) for stable
  long-term in vivo brain electrophysiology. The mesh electronics open up n
 ew windows to track single neuron changes in visual perception\, learning 
 and memory in rodent and nonhuman primate. Upon receiving his Ph.D.\, he j
 oined Dr. Eric Betzig’s lab at Howard Hughes Medical Institute Janelia R
 esearch Campus as a postdoc. Dr. Fu developed a multimodal optical scope w
 ith adaptive imaging correction (MOSAIC\, https://www.aicjanelia.org/mosai
 c) for 4D high resolution imaging of subcellular dynamics multicellular or
 ganisms\, including Caenorhabditis elegans\, Drosophila\, and zebrafish. D
 r. Fu has received recognitions including the Smith Family Graduate Scienc
 e and Engineering Fellowship and Materials Research Society (MRS) Graduate
  Student Award. His work has been selected as Top 10 World Changing Ideas 
 by Scientific American and Most Notable Research Advances of the Year by C
 hemical & Engineering News.\n 
LOCATION:https://epfl.zoom.us/j/83300544224?pwd=Nk85Z0l4cjF0TWlpZGQ4MlNqal
 lvdz09
STATUS:CONFIRMED
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