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SUMMARY:Innervation and vascularization of 3D muscle tissues: from disease
  models to therapeutic applications
DTSTART:20210302T150000
DTEND:20210302T160000
DTSTAMP:20260513T144052Z
UID:5cd354d0775e99a4f5b884d66672372ad352caf7a6fdf6399f5c6cf1
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Sébastien Uzel\nAbstract\n\nThe formation of human tissues
  that recapitulate the complex structure and function of their in vivo cou
 nterparts is a grand technological challenge and the development of advanc
 ed biomanufacturing techniques would greatly benefit many fields of applic
 ation ranging from drug development to regenerative medicine. Of particula
 r interest are muscle tissues (cardiac or skeletal)\, crucial for blood ci
 rculation or locomotion\, and whose vital activity strongly depends on the
 ir 3D architecture\, as well as their interaction with the nervous and vas
 cular systems. From the cellular scale to the organ level\, various engine
 ering tools help us shape\, control\, and interrogate such biological tiss
 ues. For example\, microfluidic systems are an excellent strategy towards 
 high throughput\, automated\, and reductionist cultures of tissue models\,
  while 3D bioprinting enables the production of complex\, large-scale and 
 perfusable organ-specific constructs for therapeutic use. In the first par
 t of my talk\, I will highlight an in vitro motor unit model to study neur
 omuscular disorders\, such as amyotrophic lateral sclerosis (ALS)\, in whi
 ch I have combined microfluidics and optogenetics to provide controlled st
 imulation of 3D neuromuscular junctions. Then\, I will describe a biomanuf
 acturing technique to assemble therapeutically relevant and cellularly den
 se cardiac constructs. This technique\, called Sacrificial Writing into Fu
 nctional Tissue (SWIFT)\, consists of the rapid free-form embedding of per
 fusable vascular channels into a living matrix composed of multicellular a
 ggregates\, such as organoids or cell spheroids. Finally\, to illustrate s
 calable manufacturing strategies\, I will present our high-throughput conf
 ormal printing method based on an adaptive multinozzle printhead design th
 at enables the rapid functionalization or repair of surfaces with arbitrar
 y topographies.\n\nBiography\nSebastien Uzel is a Research Associate at th
 e Wyss Institute for Biologically Inspired Engineering at Harvard Universi
 ty. He graduated with a Master’s Degree in Engineering Sciences from Eco
 le Centrale in Paris\, France\, where he investigated bone fracture. He th
 en moved to Cambridge\, MA\, and obtained his PhD from the Department of M
 echanical Engineering at MIT. In Prof. Kamm and Prof. So’s labs\, he des
 igned microfluidic platforms and developed optogenetic tools to mimic spin
 al cord development and control the 3D microenvironment of neuromuscular t
 issues. In 2015\, Sebastien joined Prof. Lewis’ lab at Harvard Universit
 y\, where his research focuses on developing 3D printing technologies to a
 ssemble vascularized functional biological tissues\, as well as designing 
 multinozzle printheads for high-throughput multimaterial manufacturing.\n\
 n 
LOCATION:https://epfl.zoom.us/j/84010504965?pwd=bmQ1UnkreENVUXpuSUZ5eTJWeU
 c0QT09
STATUS:CONFIRMED
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