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SUMMARY:Focused ultrasound mediated technologies towards precision medicin
 e for treatment of brain disorders
DTSTART:20210301T140000
DTEND:20210301T150000
DTSTAMP:20260919T215404Z
UID:030254ad37a11a439d51f4e6ab02c0e588c6cca1724bbbede0811758
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Mehmet Ozdas\nAbstract\n\nTechnological and scientific adva
 ncements over the last several decades elucidated the brain's staggering c
 omplexity.  Animal model studies let to insights into the underlying mech
 anisms of brain disorders\, implying the need for targeting specific brain
  circuits. However\, current treatment modalities mainly rely on systemic 
 drug administration\, which are often infective and leads to debilitating 
 side effects due to non-specific targeting of brain circuits. While severa
 l methods have been developed to modulate specific brain areas/circuits\, 
 these methods either suffer from spatial resolution or lack of molecular s
 pecificity or require highly invasive procedures. To address this unmet ne
 ed\, we developed ultrasound-controlled drug carriers (with FDA-approved c
 omponents) and novel ultrasound pulse sequences to aggregate/concentrate a
 nd subsequently uncage drugs focally within almost any brain region with m
 illimeter precision. Our technology achieves molecularly specific and spat
 ially precise targeting of brain circuits with orders of magnitude less dr
 ug than systemic drug administration to achieve similar levels of physiolo
 gical modulation of brain targets.  Our ultrasound pulse sequences use ve
 ry low powers\, thus achieving drug delivery without opening the Blood-Bra
 in Barrier. These advantages will likely lead to significant clinical bene
 fits and address many unmet needs towards precision medicine to treat vari
 ous brain disorders.\n\nBiography\n\nDr. Ozdas received his MSc in Analogu
 e and Digital Integrated Circuit Design from Imperial College London and h
 is PhD from the Swiss Federal Institute of Technology Zurich (ETH Zurich) 
 in 2019. During his PhD dissertation research at the Neurotechnology Labor
 atory of Prof. Mehmet Fatih Yanik\, he worked on focused ultrasound and ul
 trasound-sensitive drug carriers to remotely concentrate drugs in the brai
 n with millimeter resolution and with orders of magnitude higher efficienc
 y than systemic drug administration. He is currently a postdoctoral fellow
  in the Diffuse Midline Glioma Research Center of the University Children
 ’s Hospital Zurich and the Neurotechnology Laboratory of ETH Zurich\, wh
 ere he is focused on developing novel tools for therapeutic interventions 
 specifically for CNS disorders\, including intractable childhood brain tum
 ors. His research employs focused ultrasound\, in-vivo electrophysiology\,
  ultrasound-sensitive drug carriers\, and in-vivo micro-dialysis. His stud
 ies have been recognized by national and international organizations inclu
 ding the ETH Medal for outstanding PhD Thesis by ETH Zurich\, the Young In
 vestigator Award by Focused Ultrasound Foundation and the Marino Memorial 
 Talent Prize by Swiss Pediatric Oncology Group and have also been highligh
 ted by Science Magazine\, Nature Communications and others.\n\n 
LOCATION:https://epfl.zoom.us/j/81920492014?pwd=cEdhd1c5ZFRIQmMwckdPM3VYVE
 9wZz09
STATUS:CONFIRMED
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