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SUMMARY:Metal-catalyzed activation of inert molecular bonds
DTSTART:20121024T171500
DTEND:20121024T183000
DTSTAMP:20260601T143828Z
UID:3d673fae52f21d37769e772ca62d6872bbc240c6c9a30c7db4056eab
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Ruben Martin\, ICIQ\, Tarragona\, Spain\nActivation of ine
 rt entities has been and continues to be of extreme interest to any organi
 c chemist. This is especially true with activation of atmospheric molecule
 s such as CO2 or also the activation of relatively inert C-H\, C-C or C-O 
 bonds. Certainly\, the development of catalytic methods for the activation
  of the above-mentioned entities would be highly desirable\, as many of th
 e current methods involve the use of stochiometric amounts of metal comple
 xes. Recently\, our research group has reported some progress directed tow
 ards the activation of inert molecular bonds. Thus\, we reported the Pd-ca
 talyzed functionalization of C-H bonds for the synthesis of highly valuabl
 e benzocyclobutenones or a-aryl styrenes\, the preparation of benzoic acid
 s via direct carboxylation of aryl halides with CO2 and the development of
  a novel Ni-catalyzed reductive protocol fort he cleavage of inert C-O bon
 ds. These methods are characterized by their wide substrate scope\, includ
 ing challenging substrate combinations with particularly sensitive functio
 nal groups and a diverse set of substitution patterns. Additionally\, we h
 ave performed isotope-labelling experiments that support our initial mecha
 nistic hypothesis in which the key step consists of a metal-catalyzed acti
 vation of a C-O or a C-H bond\, respectively.
LOCATION:BCH 2218 https://plan.epfl.ch/?room==BCH%202218
STATUS:CONFIRMED
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