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VERSION:2.0
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SUMMARY:EPFL BioE Talks SERIES  "Protein Homeostasis at the Single Cell Le
 vel"
DTSTART:20210308T163000
DTEND:20210308T170000
DTSTAMP:20260430T125544Z
UID:9b5883b337c10eeb04d5065dbd9fa3a28e775cc892b341e3bd1cdc48
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. David Suter\, Institute of Bioengineering\, EPFL\, Lausa
 nne (CH)\nWEEKLY EPFL BIOE TALKS SERIES\n\n(note that this talk is number 
 two of a double-feature seminar - see details of the first talk here)\n\nA
 bstract:\nProtein expression levels depend on their rate of synthesis and 
 degradation. Quantitatively understanding protein expression regulation at
  the single cell level requires to measure both rates simultaneously. We h
 ave recently developed a fluorescent timer-based approach that provides a 
 quantitative readout of both synthesis and degradation of proteins in sing
 le live cells. By applying this tool to dozens of different protein-expres
 sing genes\, we determined how these rates vary over the cell cycle. We al
 so discovered that protein synthesis and degradation rates are correlated 
 at the single cell level\, which allows to buffer protein expression level
  variability. We are currently exploring how different steps of gene expre
 ssion cross-talk to allow coordinating protein synthesis and degradation r
 ates.\n\nBio:\nDavid Suter studied medicine at the University of Geneva an
 d obtained his medical diploma in 2004. He then graduated in 2007 with a P
 hD on embryonic stem cell differentiation and transgenesis in the laborato
 ry of Karl-Heinz Krause. In 2008\, he joined the Laboratory of Ueli Schibl
 er at the Department of Molecular Biology at the University of Geneva for 
 a postdoctoral training. There\, he developed a new technology allowing ul
 tra-sensitive monitoring of transcriptional kinetics in single living cell
 s by luminescence microscopy. In 2011\, he became a post-doctoral fellow i
 n the Laboratory of Xiaoliang Sunney Xie at Harvard University. Together w
 ith Christof Gebhardt\, he developed a new technology allowing to visualiz
 e and measure the residence time of single molecules of transcription fact
 ors binding to DNA. In 2013 he became tenure track assistant professor at 
 EPFL\, and has been promoted to associate professor (with tenure) in 2020.
  David Suter's laboratory is developing quantitative approaches to study g
 ene expression in single living cells\, and applying those to understand t
 he molecular bases of cell fate decisions.\n\n\nZoom link (with registrati
 on) for attending remotely: https://go.epfl.ch/EPFLBioETalks\n\n\nIMPORTAN
 T NOTICE: due to restrictions resulting from the ongoing Covid-19 pandemic
 \, this seminar can be followed via Zoom web-streaming only\, (following p
 rior one-time registration through the link above).
LOCATION:via Zoom web-streaming only\, due to Covid-19 pandemic https://go
 .epfl.ch/EPFLBioETalks https://go.epfl.ch/EPFLBioETalks
STATUS:CONFIRMED
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