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SUMMARY:EPFL BioE Talks SERIES  "Circadian Timing of Glucose and Lipid Met
 abolism"
DTSTART:20210315T160000
DTEND:20210315T170000
DTSTAMP:20260525T165945Z
UID:f333e74804c922e006ef3138d56c47a2f7b25bde7ae0a810f4f8fb42
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Charna Dibner\, University of Geneva (CH)\nWEEKLY EPFL B
 IOE TALKS SERIES\n\nAbstract:\nCircadian regulation of glucose and lipid m
 etabolism has recently caught attention\, but whether metabolite oscillati
 ons in peripheral organs are solely driven by diurnal cycles of rest/activ
 ity and food intake or are controlled in a cell autonomous manner\, has no
 t been assessed in humans. In this talk\, I shall present our recent studi
 es focusing on the molecular clocks operative in human α- and β-cells\, 
 and their role in temporal coordination of insulin and glucagon in physiol
 ogical conditions\, and in the context of type 2 diabetes. We found that i
 slet cellular clocks are indispensable for temporal orchestration of the i
 slet hormone secretion. These clocks are compromised in type 2 diabetic hu
 man islets\, resulting to perturbed temporal secretion of insulin and gluc
 agon. RORα agonist nobiletin boosting the disrupted clocks and insulin se
 cretion in human islets from type 2 diabetic donors. To uncover the roles 
 of the cell-autonomous clocks in the lipid homeostasis in human pancreatic
  islets we employed systematic mass spectrometry-based lipidomic analysis.
  Close to 10 % of the lipid metabolites from major lipid classes exhibited
  circadian oscillations in the human islets from non-diabetic donors cultu
 red and synchronized in vitro. The observed oscillations in membrane lipid
 s may indicate substantial remodeling of islet membranes on a daily basis.
  Furthermore\, we demonstrated significant alterations of the lipid metabo
 lite levels in human pancreatic islets associated with T2D\, employing the
  same approach. Observed changes in the lipid homeostasis are likely indic
 ative of an increase in the levels of inflammation and ER stress along wit
 h membrane saturation and rigidity. All together our findings suggest that
  disturbed circadian oscillators in human metabolic tissues might be impli
 cated in type 2 diabetes development in humans. Defining tissue- and disea
 se specific lipid signatures will have important diagnostic implications f
 or personalized medicine. Furthermore\, toxic lipid species accumulating u
 pon metabolic diseases represent an important therapeutic target.\n\nBio:\
 nCharna Dibner completed her PhD in Medical Sciences in 2002 under the sup
 ervision of Professor Dale Frank in the Department of Biochemistry at the 
 Technion Israel Institute of Technology\, headed by Nobel Laureate Profess
 or Avram Hershko. She completed her postdoctoral studies in the Department
  of Molecular Biology at University of Geneva\, with Professor Ueli Schibl
 er\, working on the mechanisms of transcriptional and temperature compensa
 tion of the mammalian circadian clocks. In 2009\, she was appointed as a G
 roup Leader of the Laboratory of Circadian Endocrinology in the Division o
 f Endocrinology\, Diabetes\, and Nutrition\, at the Faculty of Medicine\, 
 University of Geneva. In 2016 Charna was appointed as MER\, and from Febru
 ary 2021 as an Associate Professor at the Faculty of Medicine\, University
  of Geneva. Charna’s work centers upon the implication of circadian osci
 llators in regulation of metabolic processes in mammals. In particular\, s
 he is interested in unraveling the roles of the peripheral clocks in human
  metabolic diseases and cancer. Charna's work has been awarded with a numb
 er of prestigious Swiss prizes including Roche Research Foundation prize\,
  Takeda prize for diabetes research\, the awards by French Swiss Foundatio
 n of Diabetes Research\, and by Leenaards prize of Lemanic (French Swiss) 
 area 2019.\n\n\n\nZoom link (with registration) for attending remotely: ht
 tps://go.epfl.ch/EPFLBioETalks\n\n\nIMPORTANT NOTICE: due to restrictions 
 resulting from the ongoing Covid-19 pandemic\, this seminar can be followe
 d via Zoom web-streaming only\, (following prior one-time registration thr
 ough the link above).
LOCATION:via Zoom web-streaming only\, due to Covid-19 pandemic https://go
 .epfl.ch/EPFLBioETalks https://go.epfl.ch/EPFLBioETalks
STATUS:CONFIRMED
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