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SUMMARY:“Epigenetic deregulation in cancer: mechanisms and functional im
 pact”
DTSTART:20210422T121500
DTEND:20210422T133000
DTSTAMP:20260916T034811Z
UID:58667bdf791fe466c50edf776aa0ee8b7b5b0675904ca92984aa0484
CATEGORIES:Conferences - Seminars
DESCRIPTION:By Professor Paola Scaffidi\, Cancer Epigenetics Laboratory\, 
 The Francis Crick Institute\, London - UK Cancer Epigenetics Laboratory- P
 aola Scaffidi\nA Lola and John Grace Distinguised Lecture in Cancer Resear
 ch\n\nPaola Scaffidi has a long-standing interest in studying how deregula
 tion of gene expression leads to disease. She obtained her PhD from the Op
 en University of London\, working at San Raffaele Institute in Milan\, Ita
 ly\, where she identified the chromatin protein HMGB1 as a major danger si
 gnal that triggers sterile inflammation in damaged tissues. She then moved
  to the US National Cancer Institute to work in Tom Misteli's laboratory\,
  and studied how altered nuclear architecture contributes to the ageing pr
 ocess and cancer development. In 2014\, she established the Cancer Epigene
 tics Laboratory at the CRUK London Research Institute\, which then became 
 part of the Francis Crick Institute. A major goal of her laboratory is to 
 uncover the functional impact of epigenetic and transcriptional deregulati
 on in cancer\, and recent studies have highlighted the tight interplay bet
 ween chromatin-based mechanisms\, genetic alterations and cell-to-cell sig
 naling in defining cancer cell behavior.\n\n\n 
LOCATION:https://epfl.zoom.us/s/97039045251
STATUS:CONFIRMED
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