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SUMMARY:Revealing the physicochemical basis of biomolecular interactions w
 ith mass photometry
DTSTART:20210422T171500
DTEND:20210422T190000
DTSTAMP:20260427T225339Z
UID:6790e5a39ed3c6a39fe0e45e4eb6d391440e4c7b384aa8d493cd7efb
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Philipp KUKURA University of Oxford\, UK\nProf. Philipp 
 KUKURA\nDepartment of Chemistry\nUniversity of Oxford\, UK\nPhysical and T
 heoretical Chemistry Laboratory\, Department of Chemistry\nUniversity of O
 xford\, South Parks Road\, Oxford OX1 3QZ\, UK\n\nInteractions between bio
 molecules control the processes of life in health\, and their malfunction 
 in disease\, making their characterization and quantification essential to
  our understanding of the underlying molecular mechanisms. I will introduc
 e mass photometry\, the accurate mass measurement of individual molecules 
 in solution by light scattering\, as a general approach for studying biomo
 lecular mechanisms. The combination of label-free detection and mass measu
 rement results in universal applicability enabling study of interaction st
 oichiometries\, structure\, energetics and kinetics. I will demonstrate th
 e power of these measurements using recent results that reveal the molecul
 ar mechanisms\, enabled by the measurement of the underlying physicochemic
 al parameters\, of fundamental processes such as filament formation and se
 lf-assembly both in solution and on bilayer membranes. In combination with
  future improvements in both technical capabilities and assays\, mass phot
 ometry could make significant headway towards the ultimate goal of reveali
 ng biomolecular mechanisms directly at the molecular level.\n 
LOCATION:ZOOM https://epfl.zoom.us/j/98057582302
STATUS:CONFIRMED
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