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SUMMARY:EPFL BioE Talks SERIES  "Design of Synthetic Alternatives to Biolo
 gics in Medicine"
DTSTART:20210419T160000
DTEND:20210419T170000
DTSTAMP:20260917T070549Z
UID:2c4e8f9a8dfd9cfd43a127346bf27a1ae2d53d926fac94d4e8c2a3f9
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Suzie H. Pun\, University of Washington\, Seattle\, WA (
 USA)\nWEEKLY EPFL BIOE TALKS SERIES\n\nAbstract:\nBiologics\, products pro
 duced from living organisms\, have revolutionized treatment of disease. Ex
 amples of FDA-approved biologics include therapeutic proteins (e.g. blood 
 clotting factors and antibodies)\, engineered viruses for gene therapy\, a
 nd cell therapies. Biologics are addressing previous unmet medical needs\,
  but are challenging to manufacture and therefore high in cost. In this ta
 lk\, I will describe our efforts to develop synthetic alternatives to biol
 ogics used in medicine. In the first example\, a multivalent polymer displ
 aying a fibrin-binding peptide was developed as a synthetic alternative to
  recombinant proteins used in trauma medicine. The second example\, a poly
 mer that facilitates intracellular delivery of nucleic acids and peptides 
 was synthesized based on design principles learned from adenoviral vectors
 . In a final example\, a unique aptamer with high affinity for T cell mark
 er CD8 was discovered and applied as an alternative to antibodies for T ce
 ll isolation in the manufacturing process for CAR T cells.\n\nBio:\nSuzie 
 H. Pun is the Washington Research Foundation Professor of Bioengineering\,
  an Adjunct Professor of Chemical Engineering\, and a member of the Molecu
 lar Engineering and Sciences Institute at UW.  She is a fellow of the U.S
 . National Academy of Inventors (NAI) and American Institute of Medical an
 d Biological Engineering (AIMBE)\, and was been recognized with MIT Techno
 logy Review’s “Top 100 Young Innovators” designation\, the President
 ial Early Career Award for Scientists and Engineers in 2006\, the 2014 You
 ng Investigator Award from the Controlled Release Society\, and as an AAAS
 -Lemelson Invention Ambassador in 2015. We was recently recognized in 2018
  with the University of Washington’s Marsha Landolt Distinguished Gradua
 te Mentor Award for her dedicated mentoring of students. She currently ser
 ves as an Associate Editor for ACS Biomaterials Science and Engineering.\n
 \nSuzie Pun received her B.S. in Chemical Engineering from Stanford Univer
 sity and her Ph.D. in Chemical Engineering from the California Institute o
 f Technology. She also worked as a senior scientist at Insert Therapeutics
 /Calando Pharmaceuticals developing polymeric drug delivery systems before
  joining the Department of Bioengineering at University of Washington. Her
  current work focuses on biomaterial applications in drug delivery and gen
 e and cell therapy.\n\n\n\nZoom link (with registration) for attending rem
 otely: https://go.epfl.ch/EPFLBioETalks\n\n\nIMPORTANT NOTICE: due to rest
 rictions resulting from the ongoing Covid-19 pandemic\, this seminar can b
 e followed via Zoom web-streaming only\, (following prior one-time registr
 ation through the link above).
LOCATION:via Zoom web-streaming only\, due to Covid-19 pandemic https://go
 .epfl.ch/EPFLBioETalks https://go.epfl.ch/EPFLBioETalks
STATUS:CONFIRMED
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