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SUMMARY:L-form switching as a mechanism for antibiotic evasion
DTSTART:20210511T121500
DTEND:20210511T131500
DTSTAMP:20260506T015630Z
UID:281687f3bcdf63a4979f8936bf10815cac362a7cc49a58a9ec272621
CATEGORIES:Conferences - Seminars
DESCRIPTION:Katarzyna Mickiewicz\, The Centre for Bacterial Cell Biology\
 , Newcastle University\, U.K.\nAbstract:\nMy research focuses on an unders
 tudied mechanism of antibiotic evasion\, called L-form switching. This pro
 cess involves a transient loss of bacterial protective layer\, called the 
 cell wall\, in response to antibiotics\, which target this structure (for 
 example penicillin). Without their wall\, bacteria are susceptible to burs
 ting and slow growing\, but they can survive. Once antibiotics are gone\, 
 bacteria can rebuild the wall and resume rapid growth. Importantly\, many 
 pathogens\, including E. coli and S. aureus\, can undergo L-form switchi
 ng and it has been implicated in several recurrent diseases\, such as seps
 is\, tuberculosis\, mastitis\, urinary tract and gastrointestinal infectio
 ns\, both in human and animals. Even though L-form switching presents a po
 werful strategy for antibiotic evasion\, especially in older or immunocomp
 romised individuals\, the fragile nature of L-forms and low numbers make t
 hem very difficult to study in the host body. Therefore\, L-form switching
  in the context of the host and its impact on recurrent infection are curr
 ently poorly understood. In my talk\, I will focus on my findings regardin
 g the potential role of L-forms in recurrent urinary tract infection and d
 escribe future directions of my research.\n\nZoom\nTo join the meeting\, u
 se the following link: https://epfl.zoom.us/meeting/register/tJAkfuyoqz
 sqEtxFujqV5KheYMCUrcg31IiS to register.
LOCATION:https://epfl.zoom.us/meeting/register/tJAkfuyoqzsqEtxFujqV5KheYMC
 Urcg31IiS
STATUS:CONFIRMED
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