BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:The Malaria Parasite – Red Blood Cell Interface: Installing Tran
 sport to Survive in an Organelle-free Host Cell
DTSTART:20210507T153000
DTEND:20210507T163000
DTSTAMP:20260510T055624Z
UID:56542cd9eceec2d8f720f28026e7ad7fc905b265cfd7f3d1cce0390f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Matthias Garten\, National Institutes of Health\nTo survive in
  its organelle-free host cell\, the malaria parasite installs transport pa
 thways for proteins\, nutrients and lipids. All transport from and to the 
 host cytoplasm takes place across the parasitophorous vacuole\, the parasi
 te’s interface with the red blood cell. I aim to understand the mechanis
 ms that allow the interface to function to reveal drug targets\, make the 
 parasite more accessible to treatment and scientific research\, and aid re
 alizing the parasites potential to re-engineer red blood cells for biomedi
 cal applications. Investigating how proteins\, nutrients and lipids are tr
 ansported across the host-parasite interface\, I found that the pore of th
 e Plasmodium translocon of exported proteins (EXP2) serves a second functi
 on as nutrient permeable channel. Further\, I introduce the concept of mic
 ron-sized membrane contact sites bridging the host and parasite cytoplasm 
 for transport of lipidic substances via the parasite’s homolog of the Ni
 eman-Pick C1 protein. By uncovering the structure-function relationship at
  the host-parasite interface\, my work opens research avenues to understan
 d how the parasite connects to and controls its host cell.
LOCATION:https://epfl.zoom.us/j/61111053068?pwd=ZjducCt4YkVocnM2UVlaRmphdj
 NzUT09
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR