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SUMMARY:EPFL BioE Talks SERIES  "Mapping Precise Ramifications of Substoic
 hiometric Electrophile-Driven Cell Signaling"
DTSTART:20210510T163000
DTEND:20210510T170000
DTSTAMP:20260509T111008Z
UID:1e3dee145db01cf765ca41a2b1e614a4fc1e726d2a13592873bbb1a5
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Yimon Aye\, Laboratory of Electrophiles And Genome Opera
 tion (LEAGO)\, Institute of Chemical Sciences and Engineering\, EPFL\, Lau
 sanne (CH)\nWEEKLY EPFL BIOE TALKS SERIES\n\n(note that this talk is numbe
 r two of a double-feature seminar - see details of the first talk here)\n\
 nAbstract:\nPrecisely timed and spatially regulated electrophilic chemical
  signals are slowly being implicated as bona fide signaling events in nume
 rous cells. However\, modeling these low-stoichiometry signaling events an
 d defining the precise biological impacts of localized signals under physi
 ologic conditions has proven to be highly challenging. This seminar will s
 potlight a unique set of proximity-directed chemical biology tools that en
 ables interrogation into functional consequences of specific redox-linked 
 events: namely\, T-REX™ precision electrophile delivery and G-REX™ ele
 ctrophile-ligandability profiling in living systems\, and how using these 
 technologies have enabled us to identify bona fide “first responders” 
 that interact with native signaling electrophiles under close to endogenou
 s redox signaling conditions (i.e.\, “kcat/Km”-like). Our data show t
 hat these first responders lie at nexuses between electrophile- and canoni
 cal-signaling pathways. Thus\, these proteins translate information encode
 d by electrophiles to phosphate or ubiquitin to reroute signaling pathway 
 flux\, even at the organismal level. I will also highlight how our new abi
 lity to discover and functionally decipher precision electrophile signalin
 g mechanisms is leveraged toward novel ligand/target discovery.\n\nBio:\nU
 ndergraduate Education (2000 – 2004): University of Oxford\, UK\nGraduat
 e Education (2004 – 2009): Harvard University\, USA\nPostdoctoral Traini
 ng (2009 – 2012): MIT\, USA\nYimon Aye was born and raised in Burma. She
  moved to the UK to study for sixth form (high school) and then read chemi
 stry at Oxford University\, UK. She moved to Harvard University\, USA\, ac
 hieving a Ph.D. in organic chemistry under the supervision of Prof. David 
 A. Evans. She then moved to Massachusetts Institute of Technology (USA) to
  research the cellular and biochemical regulatory mechanisms of the enzyme
  ribonucleotide reductase with Prof. JoAnne Stubbe. In her independent car
 eer at Cornell University that began in mid-2012\, she set out to understa
 nd the detailed mechanisms of electrophile signaling. This impetus culmina
 ted in the development of “REX” technologies (T-REX™ delivery and G-
 REX™ profiling). In a parallel research program distinct from redox-depe
 ndent cell signaling\, she studies proteins/pathways involved in mammalian
  genome maintenance and nucleotide signaling\, including the mechanisms of
  anticancer agents in clinical use. As of August 2018\, she is leading the
  Laboratory of Electrophiles And Genome Operation (LEAGO) at the Institute
  of Chemical Sciences and Engineering (ISIC)\, EPFL (Switzerland) as a ten
 ured associate professor.\n\n\nZoom link (with registration) for attending
  remotely: https://go.epfl.ch/EPFLBioETalks\n\n\nIMPORTANT NOTICE: due to 
 restrictions resulting from the ongoing Covid-19 pandemic\, this seminar c
 an be followed via Zoom web-streaming only\, (following prior one-time reg
 istration through the link above).
LOCATION:via Zoom web-streaming only\, due to Covid-19 pandemic https://go
 .epfl.ch/EPFLBioETalks https://go.epfl.ch/EPFLBioETalks
STATUS:CONFIRMED
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