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SUMMARY:EPFL BioE Talks SERIES  "Hydrodynamic Flow and Concentration Gradi
 ents in the Gut Enhance Neutral Bacterial Diversity"
DTSTART:20210517T163000
DTEND:20210517T170000
DTSTAMP:20260509T131616Z
UID:470425e1b263095b80577be1bd02f39fbb1b76c65e938dd2d447dd44
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Anne-Florence Bitbol\, Institute of Bioengineering\, EPF
 L\, Lausanne (CH)\nWEEKLY EPFL BIOE TALKS SERIES\n\n(note that this talk i
 s number two of a double-feature seminar - see details of the first talk h
 ere)\n\nAbstract:\nThe gut microbiota features important genetic diversity
 \, and the specific spatial features of the gut may shape evolution within
  this environment.\nWe investigate the fixation probability of neutral bac
 terial mutants within a minimal model of the gut that includes hydrodynami
 c flow and resulting gradients of food and bacterial concentrations. We fi
 nd that this fixation probability is substantially increased compared to a
 n equivalent well-mixed system\, in the regime where the profiles of food 
 and bacterial concentration are strongly spatially-dependent. Fixation pro
 bability then becomes independent of total population size. We show that o
 ur results can be rationalized by introducing an active population\, which
  consists of those bacteria that are actively consuming food and dividing.
  The active population size yields an effective population size for neutra
 l mutant fixation probability in the gut.\n\nBio:\nAnne-Florence Bitbol st
 udied physics at ENS Lyon (F). Her PhD at Université Paris-Diderot\, advi
 sed by Prof. Jean-Baptiste Fournier\, focused on the statistics and dynami
 cs of complex membranes\, using statistical and soft matter physics to und
 erstand how lipid bilayers are perturbed by proteins or by local chemical 
 perturbations. She then chose to move even closer to biology\, as a postdo
 c in the Biophysics Theory Group at Princeton University\, led by Profs. N
 ed Wingreen\, Bill Bialek and Curt Callan. There\, she investigated the se
 lf-assembly of multi-protein complexes\, and she also worked on evolution 
 in rugged fitness landscapes with David Schwab. Next\, she became a CNRS r
 esearcher at Laboratoire Jean Perrin\, Institut de Biologie Paris-Seine\, 
 Sorbonne Université in Paris\, before moving to EPFL\, where she is a Ten
 ure-Track Assistant Professor in the Institute of Bioengineering and the S
 chool of Life Sciences. She is broadly interested in understanding biologi
 cal phenomena in a quantitative way\, through physical concepts as well as
  mathematical and computational tools. Her current research focuses on two
  main axes: the sequence-function mapping in proteins\, and the evolution 
 of microbes on complex fitness landscapes and in complex environments.\n\n
 \nZoom link (with registration) for attending remotely: https://go.epfl.ch
 /EPFLBioETalks\n\n\nIMPORTANT NOTICE: due to restrictions resulting from t
 he ongoing Covid-19 pandemic\, this seminar can be followed via Zoom web-s
 treaming only\, (following prior one-time registration through the link ab
 ove).
LOCATION:via Zoom web-streaming only\, due to Covid-19 pandemic https://go
 .epfl.ch/EPFLBioETalks https://go.epfl.ch/EPFLBioETalks
STATUS:CONFIRMED
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