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SUMMARY:EPFL BioE Talks SERIES  "Inference of Bacterial Dynamics in the Di
 gestive Tract"
DTSTART:20210517T160000
DTEND:20210517T163000
DTSTAMP:20260506T020310Z
UID:f4dcf08dcaff2b2ae4205724dc4eb8c51b8b80da6b215d8e2dd0214c
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Claude Loverdo\, Laboratoire Jean Perrin\, CNRS - Sorbon
 ne Université\, Paris (F)\nWEEKLY EPFL BIOE TALKS SERIES\n \n(note that 
 this talk is number one of a double-feature seminar - see details of the s
 econd talk here)\n\nAbstract:\nIn many animals\, the digestive tract is ho
 me to a very important microbiota\, both in numbers and in function. While
  direct in vivo visualization of the microbiota is possible for some small
  animals\, it is in general not experimentally feasible. One tool to study
  the gut microbiota in vivo is to use tagged bacteria: comparing distribut
 ion of tags at different moments in the experiment we infer biologically r
 elevant parameters using stochastic models of bacterial population dynamic
 s and branching processes. We confront estimates produced by different met
 hods for assessing the model validity\, and extend to more realistic bacte
 rial replication. We contributed to show that one main physical effect of 
 antibodies\, the main effector of the adaptive immune response secreted in
  the gut\, is to cross-link bacteria into clusters as they divide\, preven
 ting them from interacting with epithelial cells\, thus protecting the hos
 t. We then developed a simple ordinary differential equations model of the
 se bacterial clusters\, and studied how the interplay of the time scales o
 f bacterial growth and of link breaking could enable the immune system to 
 target the most problematic bacteria.\n\nBio:\nTrained as a physicist\, Cl
 aude Loverdo develops models at the interface with biology\, in collaborat
 ion with experimentalists. She did a physics PhD on first passage time in 
 biological systems in Paris\, France\, then a post-doc modeling infectious
  diseases at UCLA\, USA\, and then at the ETH\, Switzerland. She has been 
 a CNRS researcher at Sorbonne Université since 2014.\n\n\nZoom link (with
  registration) for attending remotely: https://go.epfl.ch/EPFLBioETalks\n\
 n\nIMPORTANT NOTICE: due to restrictions resulting from the ongoing Covid-
 19 pandemic\, this seminar can be followed via Zoom web-streaming only\, (
 following prior one-time registration through the link above).
LOCATION:via Zoom web-streaming only\, due to Covid-19 pandemic https://go
 .epfl.ch/EPFLBioETalks https://go.epfl.ch/EPFLBioETalks
STATUS:CONFIRMED
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