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SUMMARY:“Genetic and non-genetic routes of tumor evolution"
DTSTART:20210617T121500
DTEND:20210617T133000
DTSTAMP:20260924T112854Z
UID:9b4d04ef55128a647b79352ca080d8ff4b548f000a610ba4342f8153
CATEGORIES:Conferences - Seminars
DESCRIPTION:Giovanni Ciriello\, Associate Professor\nsince 1 August 2019 -
  Department of Computational Biology\nA specialist in computational biolog
 y and cancer genomics\, Giovanni Ciriello explores how to develop a system
 ic understanding of genetic and epigenetic modifications in the field of o
 ncology for therapeutic purposes. He has been appointed Associate Professo
 r in the Department of Computational Biology at UNIL as of 1 August 2019.\
 nA Lola and John Grace Distinguished Lecture in Cancer Research\n\nGiovann
 i Ciriello was born in 1980 and is an Italian national. He studied computa
 tional science and engineering at the University of Padua in Italy (2005).
  He then completed his PhD under the supervision of Prof. Concettina Guerr
 a\, first at the University of Padua and then at the College of Computing 
 at the Georgia Institute of Technology in Atlanta\, USA (2009). There he s
 tarted to work in the field of bioinformatics: he developed algorithms to 
 identify recurrent motifs within ribosomal RNAs and interaction sites betw
 een RNAs and proteins\, and between proteins themselves.\n\nIn 2010\, Giov
 anni Ciriello joined the laboratory of Prof. Chris Sander at Memorial Sloa
 n Kettering Cancer Center in New York\, where he is developing new computa
 tional methods for large-scale analysis of oncogenomic data. In particular
 \, he is exploring mutually exclusive (i.e. never coexisting within the sa
 me tumour type) patterns of recurrent oncogenic mutations. He is also stud
 ying how to use these recurrent alterations to identify tissue-independent
  tumour subpopulations that could benefit from the same treatment. In addi
 tion\, Giovanni Ciriello has contributed to several projects conducted wit
 hin the framework of The Cancer Genome Atlas (TCGA) research network\, of 
 which he is a member.\n\nIn April 2015\, Giovanni Ciriello was appointed a
 ssistant professor on conditional pre-tenure in the Department of Medical 
 Genetics at UNIL (renamed Department of Computational Biology in 2016). He
  is appointed associate professor as of 1 August 2019. Since his arrival i
 n Lausanne in 2015\, Giovanni Ciriello has been pursuing his research in t
 he field of oncogenetics and oncogenomics. By systematically analysing spe
 cific molecular signatures of tumour subclasses\, he predicts the conseque
 nces of these signatures at the functional and cellular level\, studies th
 eir interdependencies and explores their therapeutic implications\, such a
 s their response to treatments.\n\nWithin this framework\, the scientist's
  first line of research is to design new computational approaches to integ
 rate and analyse the different types of molecular modifications and unders
 tand how they cooperate in the tumour. He has also developed methods for t
 he systematic and comprehensive analysis of large amounts of genomic data 
 in order to explore the origin of cancers and their progression. Finally\,
  Giovanni Ciriello has also developed a translational approach by collabor
 ating with laboratories specialised in genetics and oncology to test and v
 alidate his hypotheses. The study of interdependencies between mutations h
 as opened the way to new approaches to predict the best therapy based on t
 he combination of alterations within a tumour.\n\n\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/s/97039045251
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