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SUMMARY:Taking Apart the Nuclear Envelope for Open Mitosis
DTSTART:20210706T121500
DTEND:20210706T131500
DTSTAMP:20260415T024320Z
UID:81fdb76cd31cbb694a330dd686ce07962b9f3caffbee65bd635d3ecc
CATEGORIES:Conferences - Seminars
DESCRIPTION:Ulrike Kutay\, Institute of Biochemistry\, ETHZ\nEntry into mi
 tosis is accompanied by drastic alterations in cellular organization to pr
 epare cells for division. The complete disintegration of the nuclear compa
 rtment is a hallmark of open mitosis in higher eukaryotes and well suited 
 to uncover the principles governing the rapid reorganization of cells duri
 ng prophase. In my talk\, I will touch upon two main aspects of nuclear en
 velope reorganization during mitotic entry of human cells. Firstly\, I wil
 l summarize our work on deciphering the molecular mechanisms that govern t
 he mitotic disassembly of nuclear pore complexes. Secondly\, I will presen
 t our recent work on the dissolution of NE–chromatin contacts\, which re
 vealed an unexpected role of Torsin AAA+-ATPases in modulating chromatin
  contacts established by the inner nuclear membrane protein LAP1.
LOCATION:https://epfl.zoom.us/meeting/register/tJAkfuyoqzsqEtxFujqV5KheYMC
 Urcg31IiS
STATUS:CONFIRMED
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