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SUMMARY:Target Advancement: Tool Generation and Target Validation
DTSTART;VALUE=DATE:20210928
DTSTAMP:20260601T194334Z
UID:c9b3234c0f029caa7af4e3645061d4b44e2f6abcfaf00a8f4c223685
CATEGORIES:Call for proposal
DESCRIPTION:Aim: The Target Advancement Program seeks to build conclusive 
 evidence around and develop field-enabling tools for early-stage biologica
 l targets in Parkinson’s Disease (PD) in order to enable the initiation 
 of future preclinical therapeutic programs focused on those targets. Fundi
 ng will support projects to\nvalidate early-stage targets previously impli
 cated in PD pathophysiology and/or symptomology but that have not yet been
  rigorously investigated for their ability to impact disease-relevant outc
 omes in PD model systems. For targets that are lacking preclinical tools a
 nd/or models required for validation\, the Tool Generation track provides 
 funding for the development of research-enabling preclinical tools and mod
 els to assist with the validation of the selected target.\n\nFor this roun
 d\, MJFF will not consider proposals focused on the following:\n\n	Validat
 ion of well-known targets\, including alpha-synuclein\, LRRK2\, GBA and Pa
 rkin/PINK1 given significant current investments MJFF is already making in
  these areas.\n	Applications proposing discovery studies to identify new t
 argets (e.g.\, large-scale screening or genomic/transcriptomic analyses).\
 n\nAmount: Up to $200\,000. Requested support should be commensurate with 
 work proposed.\nDuration: 18 to 24 months\nDeadline: \n\n\n	Pre-proposals 
 Due: 28 September 2021\, 5 p.m. US ET\n	Full Proposals Due (by invite only
 ): January 13\, 2022\, 5 p.m. US ET\n\nEligibility: Applications may be su
 bmitted by researchers or clinicians in:\n\n\n	U.S. and non-U.S. biotechno
 logy/pharmaceutical companies\, or other publicly or privately held for-pr
 ofit entities\; and\n	U.S. and non-U.S. public and private non-profit enti
 ties\, such as universities\, colleges\, hospitals\, laboratories\, units 
 of state and local governments and eligible agencies of the federal govern
 ment.\n	Post-doctoral fellows are eligible to apply as co-investigators wi
 th the designation of an administrative primary investigator who directs t
 he laboratory in which the fellow will conduct research. The administrativ
 e co-PI will be responsible for assisting in providing all institutional d
 ocuments required for the project and will be required to sign any award c
 ontract. Training or mentoring-only proposals will not be considered.\n\nH
 ow to Apply:\n\n\n	Download the RFA overview and application template.\n	L
 og in or create an account in the grant application portal.\n	Submit your 
 completed application.\n\nFor further Information:\n\n\n	Email grants@mich
 aeljfox.org for specific questions\n	Contact the Research Office at resear
 ch@epfl.ch if you have general questions or if you decide to submit a prop
 osal.\n\n\n 
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STATUS:CONFIRMED
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