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SUMMARY:Cellular Phenotyping in Human iPSCs
DTSTART;VALUE=DATE:20210928
DTSTAMP:20260407T152614Z
UID:e732a479a9e058120addc3d82e7ef3dce39491e866b31ef2343058ac
CATEGORIES:Call for proposal
DESCRIPTION:Aim: This program will support phenotyping of human induced pl
 uripotent stem cells (iPSCs) from our Parkinson’s Progression Markers In
 itiative (PPMI). Such work will facilitate future mechanistic studies and 
 expedite drug screening and proof-of-concept testing for Parkinson’s the
 rapeutics.\nPPMI has generated and distributed iPSCs from a subset of its 
 participants. These cell lines are coupled with robust clinical\, imaging 
 and biological data captured in the study. Recently\, MJFF-funded scientis
 ts completed deep molecular phenotyping studies in dopaminergic neurons de
 rived from these iPSCs. That data is also available.\nThis funding program
  aims to incorporate other molecular and functional phenotypic assays to f
 urther characterize the iPSCs/iPSC-derived cells from PPMI. Researchers fr
 om public and private institutions are encouraged to apply and to collabor
 ate.\nProgram Priorities:\n\n	Assessments of known PD targets and pathophy
 siologic pathways\n	Assays to characterize functional\, electrophysiologic
 al and/or neuroanatomical phenotypes\n	Assays/endpoints that can be compar
 ed to biofluid data to determine the value of iPSCs as human disease model
 s\n	Comparative assessments across different cell types (e.g.\, neurons\, 
 glia)\n	Assessments in co-culture systems to study cell autonomous and non
 -cell-autonomous phenotypes\n	Contribution of aging to PD-relevant phenoty
 pes\n	Analyses of FOUNDIN-PD data\n\nAmount:\n\n\n	Applicants may request 
 budgets ranging from $40\,000 to $200\,000 for analysis of existing datase
 ts from the PPMI iPSC sub-study and up to $1\,000\,000 for phenotypic anal
 ysis.\n	Requested budget amount will not correlate with prioritization for
  funding. Requested support should be commensurate with work proposed and 
 must include clear explanation of costs.\n\nDuration: Up to 2 years\nDeadl
 ine:\n\n\n	Pre-Proposals Due: September 28th\, 2021 5 p.m. US EST\n	Full P
 roposals Due (by invite only): January 13th\, 2022 5 p.m. US EST\n	Applica
 nts are encouraged to apply early to allow adequate time to correct errors
  found during the submission process.\n\nRequirements:\n\n\n	Assays that a
 re high-throughput or quantitative for PD relevant phenotypes\n	Funded gro
 ups must work together to compare protocols and align on QC markers so dat
 a generated across lines and across teams can be compared to one another\n
 	Teams are encouraged to deposit their differentiation protocols on protoc
 ols.io\n	Teams must adhere to the PPMI data and sample use policies\n	Team
 s must agree to deposit data back into LONI\n	Teams are expected to work c
 losely with MJFF and the FOUNDIN-PD group to support updates to the data p
 ortals and data browsers\n	Teams will consult with the relevant members of
  the PPMI SC to promote best practices in use and interpretation of PPMI d
 ata\n	Teams must be willing to participate in quarterly calls to provide u
 pdates on their study\n\nEligibility: Applications may be submitted by res
 earchers or clinicians in:\n\n\n	U.S. and non-U.S. biotechnology/pharmaceu
 tical companies\, or other publicly or privately held for-profit entities\
 ; and\n	U.S. and non-U.S. public and private non-profit entities\, such as
  universities\, colleges\, hospitals\, laboratories\, units of state and l
 ocal governments and eligible agencies of the federal government.\n	Post-d
 octoral fellows are eligible to apply as co-investigators only and with th
 e designation of an administrative primary investigator who directs the la
 boratory in which the fellow will conduct research. The administrative co-
 PI will be responsible for assisting in providing all institutional docume
 nts required for the project and will be required to sign any award contra
 ct. Training or mentoring-only proposals will not be considered.\n	As prog
 rams may require many kinds of expertise\, MJFF encourages industry and ac
 ademic collaborations when appropriate.\n\nHow to Apply:\n\n\n	Download th
 e RFA overview and application template\n	Log in or create account in the
  grant application portal\n	Submit your completed application\n\nFor Furt
 her Information:\n\n\n	Email grants@michaeljfox.org for specific informati
 on\n	Contact the Research Office at research@epfl.ch for general informati
 on and if you decide to submit a proposal\n
LOCATION:
STATUS:CONFIRMED
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