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SUMMARY:Chemical Evolution of Natural Product Structure
DTSTART:20210921T161500
DTEND:20210921T171500
DTSTAMP:20260928T185005Z
UID:0fb0b3ba27048912ac6892a74e3d163b795195cb41f69926d19adc63
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Herbert Waldmann\, Max Planck Insitute of Molecular Phys
 iology\nNatural products have provided inspiration for chemical biology an
 d medicinal chemistry research. However\, their often complex structure\, 
 and\, therefore\, demanding synthesis as well as their frequent unavailabi
 lity\, hamper their application.\nThis raises the fundamental question whe
 ther the particular structural and biological properties of natural produc
 ts can be translated to structurally less demanding compounds\, readily ac
 cessible by chemical synthesis and yet still endowed with pronounced bioac
 tivity.\nThe lecture will describe a logic for the simplification of natur
 al product structure by means of “Biology Oriented Synthesis” (BIOS) a
 nd its evolution into the “Pseudo Natural Product” (PNP) concept. Appl
 ication of natural product inspired compound collections designed and synt
 hesized following these principles in cell-based phenotypic assays and sub
 sequent identification of the cellular target proteins demonstrate that th
 e BIOS and PNPs may enable innovation in both chemical biology and medicin
 al chemistry research.\n 
LOCATION:https://epfl.zoom.us/j/62430541332
STATUS:CONFIRMED
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