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SUMMARY:ChemBio e-seminar by Dr. Jordan Meier (NIH National Cancer Institu
 te): New Insights into Acetylation & Oncometabolites from Chemoproteomics
DTSTART;VALUE=DATE:20211019
DTSTAMP:20260405T164527Z
UID:74c121f4c23ffbd9f84fa46201d3b0757ccb840066c3f63b9e7e56ff
CATEGORIES:Conferences - Seminars
DESCRIPTION:https://ccr.cancer.gov/staff-directory/jordan-l-meier#staff-pr
 ofile-lab-life-tab-9\nSeminar Title: New Insights into Acetylation & Oncom
 etabolites from Chemoproteomics\n\nAbstract: A paradox of modern biology
  is that while metabolism is known to influence epigenetic signals (includ
 ing\, but not limited to histone acetylation)\, the specific proteins that
  sense these metabolic cues remain uncharacterized. Here we describe the u
 tility of chemical methods to discover novel epigenetic mechanisms and cha
 racterize their metabolic regulation. Our initial studies have led to the
  identification of novel metabolic inhibitors of histone acetyltransferase
 s\, an expanded understanding of RNA cytidine acetylation\, and new sign
 aling functions of the covalent oncometabolite fumarate. Through our effor
 ts\, we aim to define novel biological pathways which influence the devel
 opment\, progression\, and treatment of cancer.\n\nBio: Dr. Meier receive
 d his undergraduate degree in chemistry from Creighton University in 2004\
 , getting introduced to research as an National Science Foundation REU stu
 dent. Following graduation he moved to the University of California-San Di
 ego\, performing graduate research in natural products biochemistry and pr
 oteomics under the mentorship of Professor Michael D. Burkart. After recei
 ving his Ph.D. in chemistry in 2009\, he moved to the California Institute
  of Technology. His research as an American Cancer Society postdoctoral fe
 llow in the laboratory of Professor Peter B. Dervan focused on the develop
 ment of high-throughput sequencing methods to analyze small molecule-DNA i
 nteractions. In 2013\, Dr. Meier joined the NCI\, where his research focus
 es on the development of synthetic probes to investigate metabolic and epi
 genetic signaling pathways in cancer.\n\nSpeaker's website: https://ccr.ca
 ncer.gov/staff-directory/jordan-l-meier#staff-profile-lab-life-tab-9
LOCATION:https://epfl.zoom.us/j/67855065951
STATUS:CONFIRMED
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