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SUMMARY:IMX Seminar Series - PIC hydrogels as versatile synthetic and high
 ly biomimetic matrix materials
DTSTART:20211004T131500
DTEND:20211004T141500
DTSTAMP:20260510T221500Z
UID:b57b4db021c3e99c703a3f3bd8918634c3a17bcf91552c84da0e4f39
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Paul Kouwer\, Radbud University\, The Netherlands\nRadbo
 ud University\, Institute for Molecules and Materials\, Heyendaalseweg 135
 \, 6525 AJ Nijmegen\, the Netherlands\, p.kouwer@science.ru.nl\nFibrous hy
 drogels are omnipresent in the human body. At very low protein concentrati
 ons\, they form stable\, porous networks that are the basis for mechanical
  characteristics of cytoskeleton and of the extracellular matrix. The biog
 els in our bodies are not static\; they respond to physical\, chemical and
  cellular cues that adapt their properties.\nSuch architecture and behavio
 r are not readily realized in synthetic materials. Recently\, however\, we
  developed a hydrogel that closely mimics the fibrous architecture as well
  as the linear and nonlinear mechanical properties of cytoskeletal and ext
 racellular matrix materials. The synthetic nature of the material allows u
 s to vary endlessly in molecular structure and derivatization with functio
 nal (bio)molecules.\nIn addition\, our lab studies various applications of
  the biomimetic PIC gel\, ranging from immunotherapy to wound care and den
 tal therapies to 3D cell cultures. In any application\, the PIC gel is pre
 cisely tailored in mechanical properties and biofunctionalization to drive
  the desired cell response. Mixed expertise in the research group ensures 
 that innovations in hydrogel engineering\, for instance features for in si
 tu and reversible stiffness changes\, can be directly applied in a biologi
 cal context.\nIn this talk\, I will introduce PIC gels\, their structure a
 nd approaches how to controllably change the physical and biological prope
 rties. In addition\, I will give various examples on how PIC properties ma
 y be used to affect cellular responses.\n 
LOCATION:https://epfl.zoom.us/j/63529996287
STATUS:CONFIRMED
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