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SUMMARY:IMX Seminar Series - Engineering Granular Hydrogels for Biomedical
  Applications
DTSTART:20211018T131500
DTEND:20211018T141500
DTSTAMP:20260414T071544Z
UID:4520617f993b14bf6441f8e9746170c52d264ffa83dbad189d68b41e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Jason Burdick\, University of Pennsylvania\, USA\nHydrog
 els represent a class of biomaterials that have great promise for the repa
 ir of tissues\, particularly due to our ability to engineer their biophysi
 cal and biochemical properties.  Hydrogels can provide instructive signal
 s through material properties alone (e.g.\, mechanics\, degradation\, stru
 cture) or through the delivery of therapeutics that can influence tissue m
 orphogenesis and repair.  In recent years\, we have transitioned from tra
 ditional hydrogels to granular hydrogels that are comprised of smaller hyd
 rogel units (i.e.\, microgels). Microgels can be readily fabricated throug
 h microfluidics\, with variations in microgel size\, shape\, and throughpu
 t based on device design. Granular hydrogels are formed through the packin
 g of microgels and can be designed to be injectable through shear-thinning
  behavior\, heterogeneous through microgel mixing\, and porous to support 
 cell invasion. I will give examples of the design and use of granular hydr
 ogels based on hyaluronic acid for use as injectable therapeutics for endo
 genous tissue repair or in 3D printing to fabricate hydrogel constructs. F
 or cardiac therapeutics\, we injected heterogeneous granular hydrogels int
 o the myocardium and showed selective microgel degradation to release fact
 ors and introduce porosity for cellular ingrowth. In 3D printing\, we jamm
 ed microgels to form shear-thinning and self-healing hydrogels that could 
 be printed either onto surfaces or within other hydrogels. These could be 
 cell-laden or stabilized where necessary with secondary crosslinking. As a
  last example\, we have fabricated granular hydrogels from hydrogel fibers
  that assemble into structures that permit cell encapsulation and cell-med
 iated compaction\, mimicking features of extracellular matrix. Overall\, t
 he design of granular hydrogels opens up new opportunities in the design o
 f functional hydrogels for biomedical applications.\nBio: Jason A. Burdick
 \, PhD is the Robert D. Bent Professor of Bioengineering at the University
  of Pennsylvania. Dr. Burdick’s research involves the development of hyd
 rogels through techniques such as photocrosslinking and self-assembly and 
 their processing using approaches such as electrospinning and 3D printing.
   The applications of his research range from controlling stem cell diffe
 rentiation through material cues to fabricating scaffolding for regenerati
 ve medicine and tissue repair.  Jason currently has over 275 peer-reviewe
 d publications\, he is on the editorial boards of Journal of Biomedical M
 aterials Research A\, Biofabrication\, Bioengineering\, and Advanced Heal
 thcare Materials\, and he is an Associate Editor for ACS Biomaterials Sci
 ence & Engineering. He has been recognized through numerous awards such as
  a Packard Fellowship in Science and Engineering\, an American Heart Assoc
 iation Established Investigator Award\, the Clemson Award for Basic Scienc
 e through the Society for Biomaterials\, and the Acta Biomaterialia Silver
  Medal Award. Jason has also been elected as a Fellow of the American Inst
 itute for Medical and Biological Engineering\, to the International Colleg
 e of Fellows of Biomaterials Science and Engineering\, and as a Fellow of 
 the National Academy of Inventors. Lastly\, he has founded several compani
 es to translate technology developed in his laboratory towards clinical ap
 plication.\n\n 
LOCATION:https://epfl.zoom.us/j/63529996287
STATUS:CONFIRMED
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